| Reaction Details |
|---|
 | Report a problem with these data |
| Target | Serine/threonine-protein kinase SRPK2 |
|---|
| Ligand | BDBM25121 |
|---|
| Substrate/Competitor | n/a |
|---|
| Meas. Tech. | ChEMBL_774248 |
|---|
| Kd | >10000±n/a nM |
|---|
| Citation |  Davis MI; Hunt JP; Herrgard S; Ciceri P; Wodicka LM; Pallares G; Hocker M; Treiber DK; Zarrinkar PP Comprehensive analysis of kinase inhibitor selectivity. Nat Biotechnol 29:1046-51 (2011) [PubMed] Article |
|---|
| More Info.: | Get all data from this article, Assay Method |
|---|
| |
| Serine/threonine-protein kinase SRPK2 |
|---|
| Name: | Serine/threonine-protein kinase SRPK2 |
|---|
| Synonyms: | SFRS protein kinase 2 | SR-protein-specific kinase 2 | SRSF protein kinase 2 | SRSF protein kinase 2 C-terminal | SRSF protein kinase 2 N-terminal | Serine/arginine-rich protein-specific kinase 2 |
|---|
| Type: | PROTEIN |
|---|
| Mol. Mass.: | 77488.98 |
|---|
| Organism: | Homo sapiens (Human) |
|---|
| Description: | ChEMBL_774248 |
|---|
| Residue: | 688 |
|---|
| Sequence: | MSVNSEKSSSSERPEPQQKAPLVPPPPPPPPPPPPPLPDPTPPEPEEEILGSDDEEQEDP
ADYCKGGYHPVKIGDLFNGRYHVIRKLGWGHFSTVWLCWDMQGKRFVAMKVVKSAQHYTE
TALDEIKLLKCVRESDPSDPNKDMVVQLIDDFKISGMNGIHVCMVFEVLGHHLLKWIIKS
NYQGLPVRCVKSIIRQVLQGLDYLHSKCKIIHTDIKPENILMCVDDAYVRRMAAEATEWQ
KAGAPPPSGSAVSTAPQQKPIGKISKNKKKKLKKKQKRQAELLEKRLQEIEELEREAERK
IIEENITSAAPSNDQDGEYCPEVKLKTTGLEEAAEAETAKDNGEAEDQEEKEDAEKENIE
KDEDDVDQELANIDPTWIESPKTNGHIENGPFSLEQQLDDEDDDEEDCPNPEEYNLDEPN
AESDYTYSSSYEQFNGELPNGRHKIPESQFPEFSTSLFSGSLEPVACGSVLSEGSPLTEQ
EESSPSHDRSRTVSASSTGDLPKAKTRAADLLVNPLDPRNADKIRVKIADLGNACWVHKH
FTEDIQTRQYRSIEVLIGAGYSTPADIWSTACMAFELATGDYLFEPHSGEDYSRDEDHIA
HIIELLGSIPRHFALSGKYSREFFNRRGELRHITKLKPWSLFDVLVEKYGWPHEDAAQFT
DFLIPMLEMVPEKRASAGECLRHPWLNS
|
|
|
|---|
| BDBM25121 |
|---|
| n/a |
|---|
| Name | BDBM25121 |
|---|
| Synonyms: | 4-{[(7R)-8-cyclopentyl-7-ethyl-5-methyl-6-oxo-5,6,7,8-tetrahydropteridin-2-yl]amino}-3-methoxy-N-(1-methylpiperidin-4-yl)benzamide | BI 2536 | CHEMBL513909 | US8598172, 5 |
|---|
| Type | Small organic molecule |
|---|
| Emp. Form. | C28H39N7O3 |
|---|
| Mol. Mass. | 521.6544 |
|---|
| SMILES | CC[C@H]1N(C2CCCC2)c2nc(Nc3ccc(cc3OC)C(=O)NC3CCN(C)CC3)ncc2N(C)C1=O |r| |
|---|
| Structure | 
|
|---|
Search and Browse
