| Reaction Details |
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 | Report a problem with these data |
| Target | Cyclin-dependent kinase-like 2 |
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| Ligand | BDBM50026612 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_774408 (CHEMBL1908625) |
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| Kd | 1300±n/a nM |
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| Citation |  Davis, MI; Hunt, JP; Herrgard, S; Ciceri, P; Wodicka, LM; Pallares, G; Hocker, M; Treiber, DK; Zarrinkar, PP Comprehensive analysis of kinase inhibitor selectivity. Nat Biotechnol29:1046-51 (2011) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Cyclin-dependent kinase-like 2 |
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| Name: | Cyclin-dependent kinase-like 2 |
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| Synonyms: | 2.7.11.22 | CDKL2 | CDKL2_HUMAN | Protein kinase p56 KKIAMRE | Serine/threonine-protein kinase KKIAMRE |
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| Type: | n/a |
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| Mol. Mass.: | 56031.51 |
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| Organism: | Homo sapiens (Human) |
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| Description: | Q92772 |
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| Residue: | 493 |
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| Sequence: | MEKYENLGLVGEGSYGMVMKCRNKDTGRIVAIKKFLESDDDKMVKKIAMREIKLLKQLRH
ENLVNLLEVCKKKKRWYLVFEFVDHTILDDLELFPNGLDYQVVQKYLFQIINGIGFCHSH
NIIHRDIKPENILVSQSGVVKLCDFGFARTLAAPGEVYTDYVATRWYRAPELLVGDVKYG
KAVDVWAIGCLVTEMFMGEPLFPGDSDIDQLYHIMMCLGNLIPRHQELFNKNPVFAGVRL
PEIKEREPLERRYPKLSEVVIDLAKKCLHIDPDKRPFCAELLHHDFFQMDGFAERFSQEL
QLKVQKDARNVSLSKKSQNRKKEKEKDDSLVEERKTLVVQDTNADPKIKDYKLFKIKGSK
IDGEKAEKGNRASNASCLHDSRTSHNKIVPSTSLKDCSNVSVDHTRNPSVAIPPLTHNLS
AVAPSINSGMGTETIPIQGYRVDEKTKKCSIPFVKPNRHSPSGIYNINVTTLVSGPPLSD
DSGADLPQMEHQH
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| BDBM50026612 |
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| n/a |
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| Name | BDBM50026612 |
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| Synonyms: | BIBF-1120 | Nintedanib | US10981896, Compound Nintedanib | US11046672, Nintedanib | US11208381, Nintedanib | Vargatef |
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| Type | Small organic molecule |
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| Emp. Form. | C31H33N5O4 |
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| Mol. Mass. | 539.6248 |
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| SMILES | COC(=O)c1ccc2\C(=C(\Nc3ccc(cc3)N(C)C(=O)CN3CCN(C)CC3)c3ccccc3)C(=O)Nc2c1 |
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| Structure | 
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