Ki Summary

Reaction Details

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Target

Hormonally up-regulated neu tumor-associated kinase

Ligand

BDBM60665

Substrate/Competitor

n/a

Meas. Tech.

ChEMBL_774564 (CHEMBL1908781)

>10000±n/a nM

Citation

Davis, MI; Hunt, JP; Herrgard, S; Ciceri, P; Wodicka, LM; Pallares, G; Hocker, M; Treiber, DK; Zarrinkar, PP Comprehensive analysis of kinase inhibitor selectivity. Nat Biotechnol29:1046-51 (2011) [PubMed] Article

More Info.:

Get all data from this article, Assay Method

Hormonally up-regulated neu tumor-associated kinase

Name:

Hormonally up-regulated neu tumor-associated kinase

Synonyms:

B19 | HUNK | HUNK_HUMAN | MAKV | Serine/threonine-protein kinase MAK-V

Type:

PROTEIN

Mol. Mass.:

79715.88

Organism:

Homo sapiens (Human)

Description:

ChEMBL_774564

Residue:

714

Sequence:

MPAAAGDGLLGEPAAPGGGGGAEDAARPAAACEGSFLPAWVSGVPRERLRDFQHHKRVGN
YLIGSRKLGEGSFAKVREGLHVLTGEKVAIKVIDKKRAKKDTYVTKNLRREGQIQQMIRH
PNITQLLDILETENSYYLVMELCPGGNLMHKIYEKKRLEESEARRYIRQLISAVEHLHRA
GVVHRDLKIENLLLDEDNNIKLIDFGLSNCAGILGYSDPFSTQCGSPAYAAPELLARKKY
GPKIDVWSIGVNMYAMLTGTLPFTVEPFSLRALYQKMVDKEMNPLPTQLSTGAISFLRSL
LEPDPVKRPNIQQALANRWLNENYTGKVPCNVTYPNRISLEDLSPSVVLHMTEKLGYKNS
DVINTVLSNRACHILAIYFLLNKKLERYLSGKSDIQDSLCYKTRLYQIEKYRAPKESYEA
SLDTWTRDLEFHAVQDKKPKEQEKRGDFLHRPFSKKLDKNLPSHKQPSGSLMTQIQNTKA
LLKDRKASKSSFPDKDSFGCRNIFRKTSDSNCVASSSMEFIPVPPPRTPRIVKKPEPHQP
GPGSTGIPHKEDPLMLDMVRSFESVDRDDHVEVLSPSHHYRILNSPVSLARRNSSERTLS
PGLPSGSMSPLHTPLHPTLVSFAHEDKNSPPKEEGLCCPPPVPSNGPMQPLGSPNCVKSR
GRFPMMGIGQMLRKRHQSLQPSADRPLEASLPPLQPLAPVNLAFDMADGVKTQC

BDBM60665

n/a

Name

BDBM60665

Synonyms:

BDBM50249542 | US9145414, R406 | US9212178, R406

Type

n/a

Emp. Form.

C22H23FN6O5

Mol. Mass.

470.4536

SMILES

COc1cc(Nc2ncc(F)c(Nc3ccc4OC(C)(C)C(=O)Nc4n3)n2)cc(OC)c1OC

Structure