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TargetDual specificity protein kinase CLK4
LigandBDBM50332294
Substrate/Competitorn/a
Meas. Tech.ChEMBL_774605 (CHEMBL1908822)
Kd 2000±n/a nM
Citation Davis, MI; Hunt, JP; Herrgard, S; Ciceri, P; Wodicka, LM; Pallares, G; Hocker, M; Treiber, DK; Zarrinkar, PP Comprehensive analysis of kinase inhibitor selectivity. Nat Biotechnol29:1046-51 (2011) [PubMed]  Article
More Info.:Get all data from this article,  Assay Method
 
Dual specificity protein kinase CLK4
Name:Dual specificity protein kinase CLK4
Synonyms:CDC-like kinase 4 | CLK4 | CLK4_HUMAN | Dual specificity protein kinase CLK1/CLK4
Type:Serine/threonine-protein kinase
Mol. Mass.:57522.53
Organism:Homo sapiens (Human)
Description:gi_10190706
Residue:481
Sequence:
MRHSKRTHCPDWDSRESWGHESYRGSHKRKRRSHSSTQENRHCKPHHQFKESDCHYLEAR
SLNERDYRDRRYVDEYRNDYCEGYVPRHYHRDIESGYRIHCSKSSVRSRRSSPKRKRNRH
CSSHQSRSKSHRRKRSRSIEDDEEGHLICQSGDVLRARYEIVDTLGEGAFGKVVECIDHG
MDGMHVAVKIVKNVGRYREAARSEIQVLEHLNSTDPNSVFRCVQMLEWFDHHGHVCIVFE
LLGLSTYDFIKENSFLPFQIDHIRQMAYQICQSINFLHHNKLTHTDLKPENILFVKSDYV
VKYNSKMKRDERTLKNTDIKVVDFGSATYDDEHHSTLVSTRHYRAPEVILALGWSQPCDV
WSIGCILIEYYLGFTVFQTHDSKEHLAMMERILGPIPQHMIQKTRKRKYFHHNQLDWDEH
SSAGRYVRRRCKPLKEFMLCHDEEHEKLFDLVRRMLEYDPTQRITLDEALQHPFFDLLKK
K
Blast this sequence in BindingDB or PDB
  Blast E-value cutoff:
BDBM50332294
n/a
NameBDBM50332294
Synonyms:CHEMBL1287853 | N-tert-butyl-3-(5-methyl-2-(4-(2-(pyrrolidin-1-yl)ethoxy)phenylamino)pyrimidin-4-ylamino)benzenesulfonamide | US10112907, Example 00018 | US10730860, TABLE 1.3 | US10766894, Compound TABLE 1.3 | US11203595, TABLE 1.3 | US11384069, Example T-5
TypeSmall organic molecule
Emp. Form.C27H36N6O3S
Mol. Mass.524.678
SMILESCc1cnc(Nc2ccc(OCCN3CCCC3)cc2)nc1Nc1cccc(c1)S(=O)(=O)NC(C)(C)C
Structure
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