| Reaction Details |
|---|
 | Report a problem with these data |
| Target | Mitogen-activated protein kinase kinase kinase 3 |
|---|
| Ligand | BDBM26474 |
|---|
| Substrate/Competitor | n/a |
|---|
| Meas. Tech. | ChEMBL_774345 (CHEMBL1908562) |
|---|
| Kd | >10000±n/a nM |
|---|
| Citation |  Davis, MI; Hunt, JP; Herrgard, S; Ciceri, P; Wodicka, LM; Pallares, G; Hocker, M; Treiber, DK; Zarrinkar, PP Comprehensive analysis of kinase inhibitor selectivity. Nat Biotechnol29:1046-51 (2011) [PubMed] Article |
|---|
| More Info.: | Get all data from this article, Assay Method |
|---|
| |
| Mitogen-activated protein kinase kinase kinase 3 |
|---|
| Name: | Mitogen-activated protein kinase kinase kinase 3 |
|---|
| Synonyms: | M3K3_HUMAN | MAP3K3 | MAPKKK3 | MEKK3 | Mitogen-activated protein kinase kinase kinase 3 | mitogen-activated protein kinase kinase kinase 3 isoform 1 |
|---|
| Type: | PROTEIN |
|---|
| Mol. Mass.: | 70916.05 |
|---|
| Organism: | Homo sapiens (Human) |
|---|
| Description: | ChEMBL_774345 |
|---|
| Residue: | 626 |
|---|
| Sequence: | MDEQEALNSIMNDLVALQMNRRHRMPGYETMKNKDTGHSNRQSDVRIKFEHNGERRIIAF
SRPVKYEDVEHKVTTVFGQPLDLHYMNNELSILLKNQDDLDKAIDILDRSSSMKSLRILL
LSQDRNHNSSSPHSGVSRQVRIKASQSAGDINTIYQPPEPRSRHLSVSSQNPGRSSPPPG
YVPERQQHIARQGSYTSINSEGEFIPETSEQCMLDPLSSAENSLSGSCQSLDRSADSPSF
RKSRMSRAQSFPDNRQEYSDRETQLYDKGVKGGTYPRRYHVSVHHKDYSDGRRTFPRIRR
HQGNLFTLVPSSRSLSTNGENMGLAVQYLDPRGRLRSADSENALSVQERNVPTKSPSAPI
NWRRGKLLGQGAFGRVYLCYDVDTGRELASKQVQFDPDSPETSKEVSALECEIQLLKNLQ
HERIVQYYGCLRDRAEKTLTIFMEYMPGGSVKDQLKAYGALTESVTRKYTRQILEGMSYL
HSNMIVHRDIKGANILRDSAGNVKLGDFGASKRLQTICMSGTGMRSVTGTPYWMSPEVIS
GEGYGRKADVWSLGCTVVEMLTEKPPWAEYEAMAAIFKIATQPTNPQLPSHISEHGRDFL
RRIFVEARQRPSAEELLTHHFAQLMY
|
|
|
|---|
| BDBM26474 |
|---|
| n/a |
|---|
| Name | BDBM26474 |
|---|
| Synonyms: | 5-({4-[(2,3-dimethyl-2H-indazol-6-yl)(methyl)amino]pyrimidin-2-yl}amino)-2-methylbenzene-1-sulfonamide | GW-786034 | JMC514632 Compound 13 | Pazopanib | cid_10113978 |
|---|
| Type | Small organic molecule |
|---|
| Emp. Form. | C21H23N7O2S |
|---|
| Mol. Mass. | 437.518 |
|---|
| SMILES | CN(c1ccc2c(C)n(C)nc2c1)c1ccnc(Nc2ccc(C)c(c2)S(N)(=O)=O)n1 |
|---|
| Structure | 
|
|---|
Search and Browse
