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TargetCyclin-dependent kinase 15
LigandBDBM50355501
Substrate/Competitorn/a
Meas. Tech.ChEMBL_774198
Kd>10000±n/a nM
Citation Davis MIHunt JPHerrgard SCiceri PWodicka LMPallares GHocker MTreiber DKZarrinkar PP Comprehensive analysis of kinase inhibitor selectivity. Nat Biotechnol 29:1046-51 (2011) [PubMed]  Article
More Info.:Get all data from this article,  Assay Method
 
Cyclin-dependent kinase 15
Name:Cyclin-dependent kinase 15
Synonyms:ALS2CR7 | Amyotrophic lateral sclerosis 2 chromosomal region candidate gene 7 protein | CDK15 | Cell division protein kinase 15 | PFTK2 | Serine/threonine-protein kinase ALS2CR7 | Serine/threonine-protein kinase PFTAIRE-2
Type:PROTEIN
Mol. Mass.:49029.02
Organism:Homo sapiens (Human)
Description:ChEMBL_655517
Residue:435
Sequence:
MGQELCAKTVQPGCSCYHCSEGGEAHSCRRSQPETTEAAFKLTDLKEASCSMTSFHPRGL
QAARAQKFKSKRPRSNSDCFQEEDLRQGFQWRKSLPFGAASSYLNLEKLGEGSYATVYKG
ISRINGQLVALKVISMNAEEGVPFTAIREASLLKGLKHANIVLLHDIIHTKETLTFVFEY
MHTDLAQYMSQHPGGLHPHNVRLFMFQLLRGLAYIHHQHVLHRDLKPQNLLISHLGELKL
ADFGLARAKSIPSQTYSSEVVTLWYRPPDALLGATEYSSELDIWGAGCIFIEMFQGQPLF
PGVSNILEQLEKIWEVLGVPTEDTWPGVSKLPNYNPEWFPLPTPRSLHVVWNRLGRVPEA
EDLASQMLKGFPRDRVSAQEALVHDYFSALPSQLYQLPDEESLFTVSGVRLKPEMCDLLA
SYQKGHHPAQFSKCW
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  Blast E-value cutoff:
BDBM50355501
n/a
NameBDBM50355501
Synonyms:INCB-018424 | RUXOLITINIB | RUXOLITINIB PHOSPHATE | US10112907, Example 00016
TypeSmall organic molecule
Emp. Form.C17H18N6
Mol. Mass.306.365
SMILESN#CC[C@H](C1CCCC1)n1cc(cn1)-c1ncnc2[nH]ccc12 |r|
Structure
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