| Reaction Details |
|---|
 | Report a problem with these data |
| Target | Calcium/calmodulin-dependent protein kinase type 1 |
|---|
| Ligand | BDBM50242737 |
|---|
| Substrate/Competitor | n/a |
|---|
| Meas. Tech. | ChEMBL_774402 (CHEMBL1908619) |
|---|
| Kd | 2100±n/a nM |
|---|
| Citation |  Davis, MI; Hunt, JP; Herrgard, S; Ciceri, P; Wodicka, LM; Pallares, G; Hocker, M; Treiber, DK; Zarrinkar, PP Comprehensive analysis of kinase inhibitor selectivity. Nat Biotechnol29:1046-51 (2011) [PubMed] Article |
|---|
| More Info.: | Get all data from this article, Assay Method |
|---|
| |
| Calcium/calmodulin-dependent protein kinase type 1 |
|---|
| Name: | Calcium/calmodulin-dependent protein kinase type 1 |
|---|
| Synonyms: | CAMK1 | CaM kinase I | CaM kinase I alpha | CaM-KI | CaMKI-alpha | Calcium/calmodulin-dependent protein kinase type 1 | KCC1A_HUMAN |
|---|
| Type: | PROTEIN |
|---|
| Mol. Mass.: | 41325.04 |
|---|
| Organism: | Homo sapiens (Human) |
|---|
| Description: | ChEMBL_655701 |
|---|
| Residue: | 370 |
|---|
| Sequence: | MLGAVEGPRWKQAEDIRDIYDFRDVLGTGAFSEVILAEDKRTQKLVAIKCIAKEALEGKE
GSMENEIAVLHKIKHPNIVALDDIYESGGHLYLIMQLVSGGELFDRIVEKGFYTERDASR
LIFQVLDAVKYLHDLGIVHRDLKPENLLYYSLDEDSKIMISDFGLSKMEDPGSVLSTACG
TPGYVAPEVLAQKPYSKAVDCWSIGVIAYILLCGYPPFYDENDAKLFEQILKAEYEFDSP
YWDDISDSAKDFIRHLMEKDPEKRFTCEQALQHPWIAGDTALDKNIHQSVSEQIKKNFAK
SKWKQAFNATAVVRHMRKLQLGTSQEGQGQTASHGELLTPVAGGPAAGCCCRDCCVEPGT
ELSPTLPHQL
|
|
|
|---|
| BDBM50242737 |
|---|
| n/a |
|---|
| Name | BDBM50242737 |
|---|
| Synonyms: | (R,Z)-5-(2,6-dichlorobenzylsulfonyl)-3-((3,5-dimethyl-4-(2-(pyrrolidin-1-ylmethyl)pyrrolidine-1-carbonyl)-1H-pyrrol-2-yl)methylene)indolin-2-one | CHEMBL450786 | PHA-665752 | TCMDC-125885 |
|---|
| Type | Small organic molecule |
|---|
| Emp. Form. | C32H34Cl2N4O4S |
|---|
| Mol. Mass. | 641.608 |
|---|
| SMILES | Cc1[nH]c(\C=C2/C(=O)Nc3ccc(cc23)S(=O)(=O)Cc2c(Cl)cccc2Cl)c(C)c1C(=O)N1CCC[C@@H]1CN1CCCC1 |r| |
|---|
| Structure | 
|
|---|
Search and Browse
