| Reaction Details |
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 | Report a problem with these data |
| Target | Phosphorylase b kinase gamma catalytic chain, liver/testis isoform |
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| Ligand | BDBM25118 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_774277 (CHEMBL1908494) |
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| Kd | 9000±n/a nM |
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| Citation |  Davis, MI; Hunt, JP; Herrgard, S; Ciceri, P; Wodicka, LM; Pallares, G; Hocker, M; Treiber, DK; Zarrinkar, PP Comprehensive analysis of kinase inhibitor selectivity. Nat Biotechnol29:1046-51 (2011) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Phosphorylase b kinase gamma catalytic chain, liver/testis isoform |
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| Name: | Phosphorylase b kinase gamma catalytic chain, liver/testis isoform |
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| Synonyms: | PHKG2 | PHKG2_HUMAN | Phosphorylase kinase | Phosphorylase kinase gamma subunit 2 |
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| Type: | PROTEIN |
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| Mol. Mass.: | 46440.15 |
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| Organism: | Homo sapiens (Human) |
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| Description: | ChEMBL_774277 |
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| Residue: | 406 |
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| Sequence: | MTLDVGPEDELPDWAAAKEFYQKYDPKDVIGRGVSSVVRRCVHRATGHEFAVKIMEVTAE
RLSPEQLEEVREATRRETHILRQVAGHPHIITLIDSYESSSFMFLVFDLMRKGELFDYLT
EKVALSEKETRSIMRSLLEAVSFLHANNIVHRDLKPENILLDDNMQIRLSDFGFSCHLEP
GEKLRELCGTPGYLAPEILKCSMDETHPGYGKEVDLWACGVILFTLLAGSPPFWHRRQIL
MLRMIMEGQYQFSSPEWDDRSSTVKDLISRLLQVDPEARLTAEQALQHPFFERCEGSQPW
NLTPRQRFRVAVWTVLAAGRVALSTHRVRPLTKNALLRDPYALRSVRHLIDNCAFRLYGH
WVKKGEQQNRAALFQHRPPGPFPIMGPEEEGDSAAITEDEAVLVLG
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| BDBM25118 |
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| n/a |
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| Name | BDBM25118 |
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| Synonyms: | (3Z)-4-amino-5-fluoro-3-[5-(4-methylpiperazino)-1,3-dihydrobenzimidazol-2-ylidene]carbostyril | 4-amino-5-fluoro-3-[6-(4-methylpiperazin-1-yl)-1H-1,3-benzodiazol-2-yl]-1,2-dihydroquinolin-2-one | CHEMBL522892 | CHIR-258 |
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| Type | Small organic molecule |
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| Emp. Form. | C21H21FN6O |
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| Mol. Mass. | 392.4294 |
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| SMILES | CN1CCN(CC1)c1ccc2nc([nH]c2c1)-c1c(N)c2c(F)cccc2[nH]c1=O |
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| Structure | 
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