| Reaction Details |
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 | Report a problem with these data |
| Target | Tyrosine-protein kinase Srms |
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| Ligand | BDBM26300 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_774190 (CHEMBL1908407) |
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| Kd | 7900±n/a nM |
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| Citation |  Davis, MI; Hunt, JP; Herrgard, S; Ciceri, P; Wodicka, LM; Pallares, G; Hocker, M; Treiber, DK; Zarrinkar, PP Comprehensive analysis of kinase inhibitor selectivity. Nat Biotechnol29:1046-51 (2011) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Tyrosine-protein kinase Srms |
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| Name: | Tyrosine-protein kinase Srms |
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| Synonyms: | C20orf148 | SRC | SRMS | SRMS_HUMAN |
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| Type: | Enzyme Catalytic Domain |
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| Mol. Mass.: | 54517.24 |
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| Organism: | Homo sapiens (Human) |
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| Description: | gi_18250298 |
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| Residue: | 488 |
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| Sequence: | MEPFLRRRLAFLSFFWDKIWPAGGEPDHGTPGSLDPNTDPVPTLPAEPCSPFPQLFLALY
DFTARCGGELSVRRGDRLCALEEGGGYIFARRLSGQPSAGLVPITHVAKASPETLSDQPW
YFSGVSRTQAQQLLLSPPNEPGAFLIRPSESSLGGYSLSVRAQAKVCHYRVSMAADGSLY
LQKGRLFPGLEELLTYYKANWKLIQNPLLQPCMPQKAPRQDVWERPHSEFALGRKLGEGY
FGEVWEGLWLGSLPVAIKVIKSANMKLTDLAKEIQTLKGLRHERLIRLHAVCSGGEPVYI
VTELMRKGNLQAFLGTPEGRALRLPPLLGFACQVAEGMSYLEEQRVVHRDLAARNVLVDD
GLACKVADFGLARLLKDDIYSPSSSSKIPVKWTAPEAANYRVFSQKSDVWSFGVLLHEVF
TYGQCPYEGMTNHETLQQIMRGYRLPRPAACPAEVYVLMLECWRSSPEERPSFATLREKL
HAIHRCHP
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| BDBM26300 |
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| n/a |
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| Name | BDBM26300 |
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| Synonyms: | 2-{3-[(7-{3-[ethyl(2-hydroxyethyl)amino]propoxy}quinazolin-4-yl)amino]-1H-pyrazol-5-yl}-N-(3-fluorophenyl)acetamide | CHEMBL215152 | cid_16007391 | pyrazoloquinazoline deriv., 34 |
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| Type | Small organic molecule |
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| Emp. Form. | C26H30FN7O3 |
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| Mol. Mass. | 507.5599 |
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| SMILES | CCN(CCO)CCCOc1ccc2c(Nc3cc(CC(=O)Nc4cccc(F)c4)n[nH]3)ncnc2c1 |
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| Structure | 
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