Reaction Details |
| Report a problem with these data |
Target | Megakaryocyte-associated tyrosine-protein kinase |
---|
Ligand | BDBM50322823 |
---|
Substrate/Competitor | n/a |
---|
Meas. Tech. | ChEMBL_774344 (CHEMBL1908561) |
---|
Kd | >10000±n/a nM |
---|
Citation | Davis, MI; Hunt, JP; Herrgard, S; Ciceri, P; Wodicka, LM; Pallares, G; Hocker, M; Treiber, DK; Zarrinkar, PP Comprehensive analysis of kinase inhibitor selectivity. Nat Biotechnol29:1046-51 (2011) [PubMed] Article |
---|
More Info.: | Get all data from this article, Assay Method |
---|
|
Megakaryocyte-associated tyrosine-protein kinase |
---|
Name: | Megakaryocyte-associated tyrosine-protein kinase |
Synonyms: | CTK | HYL | MATK | MATK_HUMAN | Tyrosine-protein kinase CTK |
Type: | PROTEIN |
Mol. Mass.: | 56488.45 |
Organism: | Homo sapiens (Human) |
Description: | ChEMBL_774344 |
Residue: | 507 |
Sequence: | MAGRGSLVSWRAFHGCDSAEELPRVSPRFLRAWHPPPVSARMPTRRWAPGTQCITKCEHT
RPKPGELAFRKGDVVTILEACENKSWYRVKHHTSGQEGLLAAGALREREALSADPKLSLM
PWFHGKISGQEAVQQLQPPEDGLFLVRESARHPGDYVLCVSFGRDVIHYRVLHRDGHLTI
DEAVFFCNLMDMVEHYSKDKGAICTKLVRPKRKHGTKSAEEELARAGWLLNLQHLTLGAQ
IGEGEFGAVLQGEYLGQKVAVKNIKCDVTAQAFLDETAVMTKMQHENLVRLLGVILHQGL
YIVMEHVSKGNLVNFLRTRGRALVNTAQLLQFSLHVAEGMEYLESKKLVHRDLAARNILV
SEDLVAKVSDFGLAKAERKGLDSSRLPVKWTAPEALKHGKFTSKSDVWSFGVLLWEVFSY
GRAPYPKMSLKEVSEAVEKGYRMEPPEGCPGPVHVLMSSCWEAEPARRPPFRKLAEKLAR
ELRSAGAPASVSGQDADGSTSPRSQEP
|
|
|
BDBM50322823 |
---|
n/a |
---|
Name | BDBM50322823 |
Synonyms: | (S)-N-(4-(3-chloro-4-fluorophenylamino)-7-(tetrahydrofuran-3-yloxy)quinazolin-6-yl)-4-(dimethylamino)but-2-enamide | AFATINIB | CHEMBL1173655 | US10085983, Compound BIBW2992 | US10196365, Afatinib | US10435400, Compound BIBW2992 | US9388170, Afatinib | US9890168, Compound BIBW2992 | WO2022090481, Example afatinib |
Type | Small organic molecule |
Emp. Form. | C24H25ClFN5O3 |
Mol. Mass. | 485.938 |
SMILES | CN(C)C\C=C\C(=O)Nc1cc2c(Nc3ccc(F)c(Cl)c3)ncnc2cc1O[C@H]1CCOC1 |r| |
Structure |
|