| Reaction Details |
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 | Report a problem with these data |
| Target | Serine/threonine-protein kinase ICK |
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| Ligand | BDBM4779 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_774570 (CHEMBL1908787) |
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| Kd | >10000±n/a nM |
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| Citation |  Davis, MI; Hunt, JP; Herrgard, S; Ciceri, P; Wodicka, LM; Pallares, G; Hocker, M; Treiber, DK; Zarrinkar, PP Comprehensive analysis of kinase inhibitor selectivity. Nat Biotechnol29:1046-51 (2011) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Serine/threonine-protein kinase ICK |
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| Name: | Serine/threonine-protein kinase ICK |
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| Synonyms: | CILK1 | CILK1_HUMAN | ICK | Intestinal cell kinase | KIAA0936 | LCK2 | Laryngeal cancer kinase 2 | MAK-related kinase | MRK | hICK |
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| Type: | PROTEIN |
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| Mol. Mass.: | 71470.23 |
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| Organism: | Homo sapiens (Human) |
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| Description: | ChEMBL_774570 |
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| Residue: | 632 |
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| Sequence: | MNRYTTIRQLGDGTYGSVLLGRSIESGELIAIKKMKRKFYSWEECMNLREVKSLKKLNHA
NVVKLKEVIRENDHLYFIFEYMKENLYQLIKERNKLFPESAIRNIMYQILQGLAFIHKHG
FFHRDLKPENLLCMGPELVKIADFGLAREIRSKPPYTDYVSTRWYRAPEVLLRSTNYSSP
IDVWAVGCIMAEVYTLRPLFPGASEIDTIFKICQVLGTPKKTDWPEGYQLSSAMNFRWPQ
CVPNNLKTLIPNASSEAVQLLRDMLQWDPKKRPTASQALRYPYFQVGHPLGSTTQNLQDS
EKPQKGILEKAGPPPYIKPVPPAQPPAKPHTRISSRQHQASQPPLHLTYPYKAEVSRTDH
PSHLQEDKPSPLLFPSLHNKHPQSKITAGLEHKNGEIKPKSRRRWGLISRSTKDSDDWAD
LDDLDFSPSLSRIDLKNKKRQSDDTLCRFESVLDLKPSEPVGTGNSAPTQTSYQRRDTPT
LRSAAKQHYLKHSRYLPGISIRNGILSNPGKEFIPPNPWSSSGLSGKSSGTMSVISKVNS
VGSSSTSSSGLTGNYVPSFLKKEIGSAMQRVHLAPIPDPSPGYSSLKAMRPHPGRPFFHT
QPRSTPGLIPRPPAAQPVHGRTDWASKYASRR
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| BDBM4779 |
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| n/a |
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| Name | BDBM4779 |
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| Synonyms: | CHEMBL31965 | CHEMBL545315 | CI-1033 | Canertinib | N-{4-[(3-chloro-4-fluorophenyl)amino]-7-[3-(morpholin-4-yl)propoxy]quinazolin-6-yl}prop-2-enamide | PD0183805 | US10507209, Compound CI-1033 | US9730934, CI-1033 | cid_156414 |
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| Type | Small organic molecule |
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| Emp. Form. | C24H25ClFN5O3 |
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| Mol. Mass. | 485.938 |
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| SMILES | Fc1ccc(Nc2ncnc3cc(OCCCN4CCOCC4)c(NC(=O)C=C)cc23)cc1Cl |
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| Structure | 
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