| Reaction Details |
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 | Report a problem with these data |
| Target | Megakaryocyte-associated tyrosine-protein kinase |
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| Ligand | BDBM21 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_774344 (CHEMBL1908561) |
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| Kd | >10000±n/a nM |
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| Citation |  Davis, MI; Hunt, JP; Herrgard, S; Ciceri, P; Wodicka, LM; Pallares, G; Hocker, M; Treiber, DK; Zarrinkar, PP Comprehensive analysis of kinase inhibitor selectivity. Nat Biotechnol29:1046-51 (2011) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Megakaryocyte-associated tyrosine-protein kinase |
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| Name: | Megakaryocyte-associated tyrosine-protein kinase |
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| Synonyms: | CTK | HYL | MATK | MATK_HUMAN | Tyrosine-protein kinase CTK |
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| Type: | PROTEIN |
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| Mol. Mass.: | 56488.45 |
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| Organism: | Homo sapiens (Human) |
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| Description: | ChEMBL_774344 |
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| Residue: | 507 |
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| Sequence: | MAGRGSLVSWRAFHGCDSAEELPRVSPRFLRAWHPPPVSARMPTRRWAPGTQCITKCEHT
RPKPGELAFRKGDVVTILEACENKSWYRVKHHTSGQEGLLAAGALREREALSADPKLSLM
PWFHGKISGQEAVQQLQPPEDGLFLVRESARHPGDYVLCVSFGRDVIHYRVLHRDGHLTI
DEAVFFCNLMDMVEHYSKDKGAICTKLVRPKRKHGTKSAEEELARAGWLLNLQHLTLGAQ
IGEGEFGAVLQGEYLGQKVAVKNIKCDVTAQAFLDETAVMTKMQHENLVRLLGVILHQGL
YIVMEHVSKGNLVNFLRTRGRALVNTAQLLQFSLHVAEGMEYLESKKLVHRDLAARNILV
SEDLVAKVSDFGLAKAERKGLDSSRLPVKWTAPEALKHGKFTSKSDVWSFGVLLWEVFSY
GRAPYPKMSLKEVSEAVEKGYRMEPPEGCPGPVHVLMSSCWEAEPARRPPFRKLAEKLAR
ELRSAGAPASVSGQDADGSTSPRSQEP
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| BDBM21 |
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| n/a |
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| Name | BDBM21 |
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| Synonyms: | CHEMBL24828 | N-(4-bromo-2-fluorophenyl)-6-methoxy-7-[(1-methylpiperidin-4-yl)methoxy]quinazolin-4-amine | VANDETANIB | ZD-6474 | ZD6474 | cid_3081361 |
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| Type | n/a |
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| Emp. Form. | C22H24BrFN4O2 |
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| Mol. Mass. | 475.354 |
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| SMILES | COc1cc2c(Nc3ccc(Br)cc3F)ncnc2cc1OCC1CCN(C)CC1 |
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| Structure | 
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