| Reaction Details |
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 | Report a problem with these data |
| Target | G protein-coupled receptor kinase 4 |
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| Ligand | BDBM25013 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_774219 (CHEMBL1908436) |
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| Kd | >10000±n/a nM |
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| Citation |  Davis, MI; Hunt, JP; Herrgard, S; Ciceri, P; Wodicka, LM; Pallares, G; Hocker, M; Treiber, DK; Zarrinkar, PP Comprehensive analysis of kinase inhibitor selectivity. Nat Biotechnol29:1046-51 (2011) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| G protein-coupled receptor kinase 4 |
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| Name: | G protein-coupled receptor kinase 4 |
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| Synonyms: | GPRK2L | GPRK4 | GRK4 | GRK4_HUMAN |
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| Type: | PROTEIN |
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| Mol. Mass.: | 66590.61 |
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| Organism: | Homo sapiens (Human) |
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| Description: | ChEMBL_774219 |
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| Residue: | 578 |
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| Sequence: | MELENIVANSLLLKARQGGYGKKSGRSKKWKEILTLPPVSQCSELRHSIEKDYSSLCDKQ
PIGRRLFRQFCDTKPTLKRHIEFLDAVAEYEVADDEDRSDCGLSILDRFFNDKLAAPLPE
IPPDVVTECRLGLKEENPSKKAFEECTRVAHNYLRGEPFEEYQESSYFSQFLQWKWLERQ
PVTKNTFRHYRVLGKGGFGEVCACQVRATGKMYACKKLQKKRIKKRKGEAMALNEKRILE
KVQSRFVVSLAYAYETKDALCLVLTIMNGGDLKFHIYNLGNPGFDEQRAVFYAAELCCGL
EDLQRERIVYRDLKPENILLDDRGHIRISDLGLATEIPEGQRVRGRVGTVGYMAPEVVNN
EKYTFSPDWWGLGCLIYEMIQGHSPFKKYKEKVKWEEVDQRIKNDTEEYSEKFSEDAKSI
CRMLLTKNPSKRLGCRGEGAAGVKQHPVFKDINFRRLEANMLEPPFCPDPHAVYCKDVLD
IEQFSVVKGIYLDTADEDFYARFATGCVSIPWQNEMIESGCFKDINKSESEEALPLDLDK
NIHTPVSRPNRGFFYRLFRRGGCLTMVPSEKEVEPKQC
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| BDBM25013 |
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| n/a |
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| Name | BDBM25013 |
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| Synonyms: | 4-[2-(4-amino-1,2,5-oxadiazol-3-yl)-1-ethyl-7-[(3S)-piperidin-3-ylmethoxy]-1H-imidazo[4,5-c]pyridin-4-yl]-2-methylbut-3-yn-2-ol | GSK-690693 | GSK690693 | US10550114, Compound GSK690693 |
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| Type | Small organic molecule |
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| Emp. Form. | C21H27N7O3 |
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| Mol. Mass. | 425.4842 |
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| SMILES | CCn1c(nc2c(ncc(OC[C@H]3CCCNC3)c12)C#CC(C)(C)O)-c1nonc1N |r| |
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| Structure | 
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