| Reaction Details |
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 | Report a problem with these data |
| Target | Cyclin-dependent kinase 15 |
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| Ligand | BDBM4779 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_774198 (CHEMBL1908415) |
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| Kd | >10000±n/a nM |
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| Citation |  Davis, MI; Hunt, JP; Herrgard, S; Ciceri, P; Wodicka, LM; Pallares, G; Hocker, M; Treiber, DK; Zarrinkar, PP Comprehensive analysis of kinase inhibitor selectivity. Nat Biotechnol29:1046-51 (2011) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Cyclin-dependent kinase 15 |
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| Name: | Cyclin-dependent kinase 15 |
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| Synonyms: | ALS2CR7 | Amyotrophic lateral sclerosis 2 chromosomal region candidate gene 7 protein | CDK15 | CDK15_HUMAN | Cell division protein kinase 15 | PFTK2 | Serine/threonine-protein kinase ALS2CR7 | Serine/threonine-protein kinase PFTAIRE-2 |
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| Type: | PROTEIN |
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| Mol. Mass.: | 49029.02 |
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| Organism: | Homo sapiens (Human) |
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| Description: | ChEMBL_655517 |
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| Residue: | 435 |
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| Sequence: | MGQELCAKTVQPGCSCYHCSEGGEAHSCRRSQPETTEAAFKLTDLKEASCSMTSFHPRGL
QAARAQKFKSKRPRSNSDCFQEEDLRQGFQWRKSLPFGAASSYLNLEKLGEGSYATVYKG
ISRINGQLVALKVISMNAEEGVPFTAIREASLLKGLKHANIVLLHDIIHTKETLTFVFEY
MHTDLAQYMSQHPGGLHPHNVRLFMFQLLRGLAYIHHQHVLHRDLKPQNLLISHLGELKL
ADFGLARAKSIPSQTYSSEVVTLWYRPPDALLGATEYSSELDIWGAGCIFIEMFQGQPLF
PGVSNILEQLEKIWEVLGVPTEDTWPGVSKLPNYNPEWFPLPTPRSLHVVWNRLGRVPEA
EDLASQMLKGFPRDRVSAQEALVHDYFSALPSQLYQLPDEESLFTVSGVRLKPEMCDLLA
SYQKGHHPAQFSKCW
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| BDBM4779 |
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| n/a |
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| Name | BDBM4779 |
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| Synonyms: | CHEMBL31965 | CHEMBL545315 | CI-1033 | Canertinib | N-{4-[(3-chloro-4-fluorophenyl)amino]-7-[3-(morpholin-4-yl)propoxy]quinazolin-6-yl}prop-2-enamide | PD0183805 | US10507209, Compound CI-1033 | US9730934, CI-1033 | cid_156414 |
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| Type | Small organic molecule |
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| Emp. Form. | C24H25ClFN5O3 |
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| Mol. Mass. | 485.938 |
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| SMILES | Fc1ccc(Nc2ncnc3cc(OCCCN4CCOCC4)c(NC(=O)C=C)cc23)cc1Cl |
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| Structure | 
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