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TargetRenin
LigandBDBM50355534
Substrate/Competitorn/a
Meas. Tech.ChEMBL_776557 (CHEMBL1913654)
IC50 0.07±n/a nM
Citation Chen, ACauchon, EChefson, ADolman, SDucharme, YDubé, DFalgueyret, JPFournier, PAGagné, SGallant, MGrimm, EHan, YHoule, RHuang, JQHughes, GJûteau, HLacombe, PLauzon, SLévesque, JFLiu, SMacdonald, DMackay, BMcKay, DPercival, MDSt-Jacques, RToulmond, S Renin inhibitors for the treatment of hypertension: design and optimization of a novel series of tertiary alcohol-bearing piperidines. Bioorg Med Chem Lett21:3976-81 (2011) [PubMed]  Article
More Info.:Get all data from this article,  Assay Method
 
Renin
Name:Renin
Synonyms:Angiotensinogenase | REN | RENI_HUMAN
Type:Enzyme
Mol. Mass.:45058.99
Organism:Homo sapiens (Human)
Description:n/a
Residue:406
Sequence:
MDGWRRMPRWGLLLLLWGSCTFGLPTDTTTFKRIFLKRMPSIRESLKERGVDMARLGPEW
SQPMKRLTLGNTTSSVILTNYMDTQYYGEIGIGTPPQTFKVVFDTGSSNVWVPSSKCSRL
YTACVYHKLFDASDSSSYKHNGTELTLRYSTGTVSGFLSQDIITVGGITVTQMFGEVTEM
PALPFMLAEFDGVVGMGFIEQAIGRVTPIFDNIISQGVLKEDVFSFYYNRDSENSQSLGG
QIVLGGSDPQHYEGNFHYINLIKTGVWQIQMKGVSVGSSTLLCEDGCLALVDTGASYISG
STSSIEKLMEALGAKKRLFDYVVKCNEGPTLPDISFHLGGKEYTLTSADYVFQESYSSKK
LCTLAIHAMDIPPPTGPTWALGATFIRKFYTEFDRRNNRIGFALAR
Blast this sequence in BindingDB or PDB
  Blast E-value cutoff:
BDBM50355534
n/a
NameBDBM50355534
Synonyms:CHEMBL1910300
TypeSmall organic molecule
Emp. Form.C28H32F3N3O3
Mol. Mass.515.5672
SMILESCOCCCn1cc(CN(C2CC2)C(=O)[C@H]2CNCC[C@]2(O)c2ccc(F)c(F)c2)c2c(F)cccc12 |r|
Structure
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