| Reaction Details |
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 | Report a problem with these data |
| Target | Protein-arginine deiminase type-2 |
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| Ligand | BDBM50355665 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_776879 (CHEMBL1914013) |
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| IC50 | 6200±n/a nM |
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| Citation |  Causey, CP; Jones, JE; Slack, JL; Kamei, D; Jones, LE; Subramanian, V; Knuckley, B; Ebrahimi, P; Chumanevich, AA; Luo, Y; Hashimoto, H; Sato, M; Hofseth, LJ; Thompson, PR The development of N-a-(2-carboxyl)benzoyl-N(5)-(2-fluoro-1-iminoethyl)-l-ornithine amide (o-F-amidine) and N-a-(2-carboxyl)benzoyl-N(5)-(2-chloro-1-iminoethyl)-l-ornithine amide (o-Cl-amidine) as second generation protein arginine deiminase (PAD) inhibitors. J Med Chem54:6919-35 (2011) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Protein-arginine deiminase type-2 |
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| Name: | Protein-arginine deiminase type-2 |
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| Synonyms: | KIAA0994 | PAD-H19 | PAD2 | PADI2 | PADI2_HUMAN | PDI2 | Peptidylarginine deiminase II | Protein-arginine deiminase type II |
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| Type: | PROTEIN |
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| Mol. Mass.: | 75552.49 |
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| Organism: | Homo sapiens (Human) |
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| Description: | ChEMBL_1290379 |
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| Residue: | 665 |
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| Sequence: | MLRERTVRLQYGSRVEAVYVLGTYLWTDVYSAAPAGAQTFSLKHSEHVWVEVVRDGEAEE
VATNGKQRWLLSPSTTLRVTMSQASTEASSDKVTVNYYDEEGSIPIDQAGLFLTAIEISL
DVDADRDGVVEKNNPKKASWTWGPEGQGAILLVNCDRETPWLPKEDCRDEKVYSKEDLKD
MSQMILRTKGPDRLPAGYEIVLYISMSDSDKVGVFYVENPFFGQRYIHILGRRKLYHVVK
YTGGSAELLFFVEGLCFPDEGFSGLVSIHVSLLEYMAQDIPLTPIFTDTVIFRIAPWIMT
PNILPPVSVFVCCMKDNYLFLKEVKNLVEKTNCELKVCFQYLNRGDRWIQDEIEFGYIEA
PHKGFPVVLDSPRDGNLKDFPVKELLGPDFGYVTREPLFESVTSLDSFGNLEVSPPVTVN
GKTYPLGRILIGSSFPLSGGRRMTKVVRDFLKAQQVQAPVELYSDWLTVGHVDEFMSFVP
IPGTKKFLLLMASTSACYKLFREKQKDGHGEAIMFKGLGGMSSKRITINKILSNESLVQE
NLYFQRCLDWNRDILKKELGLTEQDIIDLPALFKMDEDHRARAFFPNMVNMIVLDKDLGI
PKPFGPQVEEECCLEMHVRGLLEPLGLECTFIDDISAYHKFLGEVHCGTNVRRKPFTFKW
WHMVP
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| BDBM50355665 |
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| n/a |
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| Name | BDBM50355665 |
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| Synonyms: | CHEMBL1910971 |
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| Type | Small organic molecule |
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| Emp. Form. | C15H19ClN4O4 |
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| Mol. Mass. | 354.789 |
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| SMILES | NC(CCl)=NCCC[C@H](NC(=O)c1ccccc1C(O)=O)C(N)=O |r,w:4.4| |
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| Structure | 
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