Reaction Details |
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Target | Protein-arginine deiminase type-2 |
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Ligand | BDBM50355658 |
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Substrate/Competitor | n/a |
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Meas. Tech. | ChEMBL_776879 (CHEMBL1914013) |
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IC50 | 51000±n/a nM |
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Citation | Causey, CP; Jones, JE; Slack, JL; Kamei, D; Jones, LE; Subramanian, V; Knuckley, B; Ebrahimi, P; Chumanevich, AA; Luo, Y; Hashimoto, H; Sato, M; Hofseth, LJ; Thompson, PR The development of N-a-(2-carboxyl)benzoyl-N(5)-(2-fluoro-1-iminoethyl)-l-ornithine amide (o-F-amidine) and N-a-(2-carboxyl)benzoyl-N(5)-(2-chloro-1-iminoethyl)-l-ornithine amide (o-Cl-amidine) as second generation protein arginine deiminase (PAD) inhibitors. J Med Chem54:6919-35 (2011) [PubMed] Article |
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More Info.: | Get all data from this article, Assay Method |
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Protein-arginine deiminase type-2 |
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Name: | Protein-arginine deiminase type-2 |
Synonyms: | KIAA0994 | PAD-H19 | PAD2 | PADI2 | PADI2_HUMAN | PDI2 | Peptidylarginine deiminase II | Protein-arginine deiminase type II |
Type: | PROTEIN |
Mol. Mass.: | 75552.49 |
Organism: | Homo sapiens (Human) |
Description: | ChEMBL_1290379 |
Residue: | 665 |
Sequence: | MLRERTVRLQYGSRVEAVYVLGTYLWTDVYSAAPAGAQTFSLKHSEHVWVEVVRDGEAEE
VATNGKQRWLLSPSTTLRVTMSQASTEASSDKVTVNYYDEEGSIPIDQAGLFLTAIEISL
DVDADRDGVVEKNNPKKASWTWGPEGQGAILLVNCDRETPWLPKEDCRDEKVYSKEDLKD
MSQMILRTKGPDRLPAGYEIVLYISMSDSDKVGVFYVENPFFGQRYIHILGRRKLYHVVK
YTGGSAELLFFVEGLCFPDEGFSGLVSIHVSLLEYMAQDIPLTPIFTDTVIFRIAPWIMT
PNILPPVSVFVCCMKDNYLFLKEVKNLVEKTNCELKVCFQYLNRGDRWIQDEIEFGYIEA
PHKGFPVVLDSPRDGNLKDFPVKELLGPDFGYVTREPLFESVTSLDSFGNLEVSPPVTVN
GKTYPLGRILIGSSFPLSGGRRMTKVVRDFLKAQQVQAPVELYSDWLTVGHVDEFMSFVP
IPGTKKFLLLMASTSACYKLFREKQKDGHGEAIMFKGLGGMSSKRITINKILSNESLVQE
NLYFQRCLDWNRDILKKELGLTEQDIIDLPALFKMDEDHRARAFFPNMVNMIVLDKDLGI
PKPFGPQVEEECCLEMHVRGLLEPLGLECTFIDDISAYHKFLGEVHCGTNVRRKPFTFKW
WHMVP
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BDBM50355658 |
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n/a |
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Name | BDBM50355658 |
Synonyms: | CHEMBL1910973 |
Type | Small organic molecule |
Emp. Form. | C14H19FN4O2 |
Mol. Mass. | 294.3247 |
SMILES | NC(=O)[C@H](CCCN=C(N)CF)NC(=O)c1ccccc1 |r,w:7.6| |
Structure |
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