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TargetTranslocator protein
LigandBDBM50355786
Substrate/Competitorn/a
Meas. Tech.ChEMBL_776493 (CHEMBL1913590)
IC50 0.28±n/a nM
Citation Cappelli, ABini, GValenti, SGiuliani, GPaolino, MAnzini, MVomero, SGiorgi, GGiordani, AStasi, LPMakovec, FGhelardini, CDi Cesare Mannelli, LConcas, APorcu, PBiggio, G Synthesis and structure-activity relationship studies in translocator protein ligands based on a pyrazolo[3,4-b]quinoline scaffold. J Med Chem54:7165-75 (2011) [PubMed]  Article
More Info.:Get all data from this article,  Assay Method
 
Translocator protein
Name:Translocator protein
Synonyms:Benzodiazepine receptors; peripheral & central | Bzrp | Mbr | Mitochondrial benzodiazepine receptor | PBR | PKBS | Peripheral benzodiazepine receptor (PBR) | Peripheral-Type Benzodiazepine Receptor | TSPO_RAT | Tspo
Type:Mitochondrion membrane protein
Mol. Mass.:18945.84
Organism:Rattus norvegicus (rat)
Description:Competitive binding experiments were performed on rat kidney mitochondrial membranes.
Residue:169
Sequence:
MSQSWVPAVGLTLVPSLGGFMGAYFVRGEGLRWYASLQKPSWHPPRWTLAPIWGTLYSAM
GYGSYIIWKELGGFTEEAMVPLGLYTGQLALNWAWPPIFFGARQMGWALVDLMLVSGVAT
ATTLAWHRVSPPAARLLYPYLAWLAFATMLNYYVWRDNSGRRGGSRLTE
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BDBM50355786
n/a
NameBDBM50355786
Synonyms:CHEMBL1911625
TypeSmall organic molecule
Emp. Form.C26H20ClFN4O2
Mol. Mass.474.914
SMILESCN(C(=O)Cn1c2nn(-c3ccc(F)cc3)c(=O)c2c(C)c2ccccc12)c1ccc(Cl)cc1
Structure
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