Reaction Details |
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Target | Translocator protein |
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Ligand | BDBM50355786 |
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Substrate/Competitor | n/a |
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Meas. Tech. | ChEMBL_776493 (CHEMBL1913590) |
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IC50 | 0.28±n/a nM |
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Citation | Cappelli, A; Bini, G; Valenti, S; Giuliani, G; Paolino, M; Anzini, M; Vomero, S; Giorgi, G; Giordani, A; Stasi, LP; Makovec, F; Ghelardini, C; Di Cesare Mannelli, L; Concas, A; Porcu, P; Biggio, G Synthesis and structure-activity relationship studies in translocator protein ligands based on a pyrazolo[3,4-b]quinoline scaffold. J Med Chem54:7165-75 (2011) [PubMed] Article |
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More Info.: | Get all data from this article, Assay Method |
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Translocator protein |
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Name: | Translocator protein |
Synonyms: | Benzodiazepine receptors; peripheral & central | Bzrp | Mbr | Mitochondrial benzodiazepine receptor | PBR | PKBS | Peripheral benzodiazepine receptor (PBR) | Peripheral-Type Benzodiazepine Receptor | TSPO_RAT | Tspo |
Type: | Mitochondrion membrane protein |
Mol. Mass.: | 18945.84 |
Organism: | Rattus norvegicus (rat) |
Description: | Competitive binding experiments were performed on rat kidney mitochondrial membranes. |
Residue: | 169 |
Sequence: | MSQSWVPAVGLTLVPSLGGFMGAYFVRGEGLRWYASLQKPSWHPPRWTLAPIWGTLYSAM
GYGSYIIWKELGGFTEEAMVPLGLYTGQLALNWAWPPIFFGARQMGWALVDLMLVSGVAT
ATTLAWHRVSPPAARLLYPYLAWLAFATMLNYYVWRDNSGRRGGSRLTE
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BDBM50355786 |
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n/a |
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Name | BDBM50355786 |
Synonyms: | CHEMBL1911625 |
Type | Small organic molecule |
Emp. Form. | C26H20ClFN4O2 |
Mol. Mass. | 474.914 |
SMILES | CN(C(=O)Cn1c2nn(-c3ccc(F)cc3)c(=O)c2c(C)c2ccccc12)c1ccc(Cl)cc1 |
Structure |
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