Reaction Details |
| Report a problem with these data |
Target | Translocator protein |
---|
Ligand | BDBM22032 |
---|
Substrate/Competitor | n/a |
---|
Meas. Tech. | ChEMBL_776493 (CHEMBL1913590) |
---|
IC50 | 1.3±n/a nM |
---|
Citation | Cappelli, A; Bini, G; Valenti, S; Giuliani, G; Paolino, M; Anzini, M; Vomero, S; Giorgi, G; Giordani, A; Stasi, LP; Makovec, F; Ghelardini, C; Di Cesare Mannelli, L; Concas, A; Porcu, P; Biggio, G Synthesis and structure-activity relationship studies in translocator protein ligands based on a pyrazolo[3,4-b]quinoline scaffold. J Med Chem54:7165-75 (2011) [PubMed] Article |
---|
More Info.: | Get all data from this article, Assay Method |
---|
|
Translocator protein |
---|
Name: | Translocator protein |
Synonyms: | Benzodiazepine receptors; peripheral & central | Bzrp | Mbr | Mitochondrial benzodiazepine receptor | PBR | PKBS | Peripheral benzodiazepine receptor (PBR) | Peripheral-Type Benzodiazepine Receptor | TSPO_RAT | Tspo |
Type: | Mitochondrion membrane protein |
Mol. Mass.: | 18945.84 |
Organism: | Rattus norvegicus (rat) |
Description: | Competitive binding experiments were performed on rat kidney mitochondrial membranes. |
Residue: | 169 |
Sequence: | MSQSWVPAVGLTLVPSLGGFMGAYFVRGEGLRWYASLQKPSWHPPRWTLAPIWGTLYSAM
GYGSYIIWKELGGFTEEAMVPLGLYTGQLALNWAWPPIFFGARQMGWALVDLMLVSGVAT
ATTLAWHRVSPPAARLLYPYLAWLAFATMLNYYVWRDNSGRRGGSRLTE
|
|
|
BDBM22032 |
---|
n/a |
---|
Name | BDBM22032 |
Synonyms: | 1-(2-chlorophenyl)-N-methyl-N-(1-methylpropyl)isoquinoline-3-carboxamide | CHEMBL15313 | N-(butan-2-yl)-1-(2-chlorophenyl)-N-methylisoquinoline-3-carboxamide | PK 11195 | PK-11195 | PK11195 | RP 52028 | [3H]PK 11195 |
Type | radiolabeled ligand |
Emp. Form. | C21H21ClN2O |
Mol. Mass. | 352.857 |
SMILES | CCC(C)N(C)C(=O)c1cc2ccccc2c(n1)-c1ccccc1Cl |
Structure |
|