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TargetCeramide glucosyltransferase
LigandBDBM50356074
Substrate/Competitorn/a
Meas. Tech.ChEMBL_775861
IC50 7±n/a nM
Citation Koltun ERichards SChan VNachtigall JDu HNoson KGalan AAay NHanel AHarrison AZhang JWon KATam DQian FWang TFinn POgilvie KRosen JMohan RLarson CLamb PNuss JKearney P Discovery of a new class of glucosylceramide synthase inhibitors. Bioorg Med Chem Lett 21:6773-7 (2011) [PubMed]  Article
More Info.:Get all data from this article,  Assay Method
 
Ceramide glucosyltransferase
Name:Ceramide glucosyltransferase
Synonyms:GCS | GLCT-1 | Glucosylceramide synthase | UDP-glucose ceramide glucosyltransferase | UDP-glucose:N-acylsphingosine D-glucosyltransferase
Type:PROTEIN
Mol. Mass.:44859.25
Organism:Homo sapiens (Human)
Description:ChEMBL_1435474
Residue:394
Sequence:
MALLDLALEGMAVFGFVLFLVLWLMHFMAIIYTRLHLNKKATDKQPYSKLPGVSLLKPLK
GVDPNLINNLETFFELDYPKYEVLLCVQDHDDPAIDVCKKLLGKYPNVDARLFIGGKKVG
INPKINNLMPGYEVAKYDLIWICDSGIRVIPDTLTDMVNQMTEKVGLVHGLPYVADRQGF
AATLEQVYFGTSHPRYYISANVTGFKCVTGMSCLMRKDVLDQAGGLIAFAQYIAEDYFMA
KAIADRGWRFAMSTQVAMQNSGSYSISQFQSRMIRWTKLRINMLPATIICEPISECFVAS
LIIGWAAHHVFRWDIMVFFMCHCLAWFIFDYIQLRGVQGGTLCFSKLDYAVAWFIRESMT
IYIFLSALWDPTISWRTGRYRLRCGGTAEEILDV
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  Blast E-value cutoff:
BDBM50356074
n/a
NameBDBM50356074
Synonyms:CHEMBL1911819
TypeSmall organic molecule
Emp. Form.C28H27ClF4N4O4
Mol. Mass.594.985
SMILESCN1CCN(CC1)C(=O)[C@@H](COCc1ccc(F)cc1)NC(=O)c1cccnc1Oc1ccc(cc1Cl)C(F)(F)F |r|
Structure
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