| Reaction Details |
|---|
 | Report a problem with these data |
| Target | Ceramide glucosyltransferase |
|---|
| Ligand | BDBM50356079 |
|---|
| Substrate/Competitor | n/a |
|---|
| Meas. Tech. | ChEMBL_775861 (CHEMBL1912402) |
|---|
| IC50 | 3±n/a nM |
|---|
| Citation |  Koltun, E; Richards, S; Chan, V; Nachtigall, J; Du, H; Noson, K; Galan, A; Aay, N; Hanel, A; Harrison, A; Zhang, J; Won, KA; Tam, D; Qian, F; Wang, T; Finn, P; Ogilvie, K; Rosen, J; Mohan, R; Larson, C; Lamb, P; Nuss, J; Kearney, P Discovery of a new class of glucosylceramide synthase inhibitors. Bioorg Med Chem Lett21:6773-7 (2011) [PubMed] Article |
|---|
| More Info.: | Get all data from this article, Assay Method |
|---|
| |
| Ceramide glucosyltransferase |
|---|
| Name: | Ceramide glucosyltransferase |
|---|
| Synonyms: | CEGT_HUMAN | GCS | GLCT-1 | Glucosylceramide synthase | UDP-glucose ceramide glucosyltransferase | UDP-glucose:N-acylsphingosine D-glucosyltransferase | UGCG |
|---|
| Type: | PROTEIN |
|---|
| Mol. Mass.: | 44859.25 |
|---|
| Organism: | Homo sapiens (Human) |
|---|
| Description: | ChEMBL_1435474 |
|---|
| Residue: | 394 |
|---|
| Sequence: | MALLDLALEGMAVFGFVLFLVLWLMHFMAIIYTRLHLNKKATDKQPYSKLPGVSLLKPLK
GVDPNLINNLETFFELDYPKYEVLLCVQDHDDPAIDVCKKLLGKYPNVDARLFIGGKKVG
INPKINNLMPGYEVAKYDLIWICDSGIRVIPDTLTDMVNQMTEKVGLVHGLPYVADRQGF
AATLEQVYFGTSHPRYYISANVTGFKCVTGMSCLMRKDVLDQAGGLIAFAQYIAEDYFMA
KAIADRGWRFAMSTQVAMQNSGSYSISQFQSRMIRWTKLRINMLPATIICEPISECFVAS
LIIGWAAHHVFRWDIMVFFMCHCLAWFIFDYIQLRGVQGGTLCFSKLDYAVAWFIRESMT
IYIFLSALWDPTISWRTGRYRLRCGGTAEEILDV
|
|
|
|---|
| BDBM50356079 |
|---|
| n/a |
|---|
| Name | BDBM50356079 |
|---|
| Synonyms: | CHEMBL1911814 |
|---|
| Type | Small organic molecule |
|---|
| Emp. Form. | C27H27Cl2FN4O4 |
|---|
| Mol. Mass. | 561.432 |
|---|
| SMILES | CN1CCN(CC1)C(=O)[C@@H](COCc1ccccc1)NC(=O)c1cc(F)cnc1Oc1ccc(Cl)cc1Cl |r| |
|---|
| Structure | 
|
|---|
Search and Browse
