Ki Summary BindingDB logo
myBDB logout
Reaction Details
Report a problem with these data
TargetCeramide glucosyltransferase
LigandBDBM50356076
Substrate/Competitorn/a
Meas. Tech.ChEMBL_775862 (CHEMBL1912403)
IC50 2±n/a nM
Citation Koltun, ERichards, SChan, VNachtigall, JDu, HNoson, KGalan, AAay, NHanel, AHarrison, AZhang, JWon, KATam, DQian, FWang, TFinn, POgilvie, KRosen, JMohan, RLarson, CLamb, PNuss, JKearney, P Discovery of a new class of glucosylceramide synthase inhibitors. Bioorg Med Chem Lett21:6773-7 (2011) [PubMed]  Article
More Info.:Get all data from this article,  Assay Method
 
Ceramide glucosyltransferase
Name:Ceramide glucosyltransferase
Synonyms:CEGT_HUMAN | GCS | GLCT-1 | Glucosylceramide synthase | UDP-glucose ceramide glucosyltransferase | UDP-glucose:N-acylsphingosine D-glucosyltransferase | UGCG
Type:PROTEIN
Mol. Mass.:44859.25
Organism:Homo sapiens (Human)
Description:ChEMBL_1435474
Residue:394
Sequence:
MALLDLALEGMAVFGFVLFLVLWLMHFMAIIYTRLHLNKKATDKQPYSKLPGVSLLKPLK
GVDPNLINNLETFFELDYPKYEVLLCVQDHDDPAIDVCKKLLGKYPNVDARLFIGGKKVG
INPKINNLMPGYEVAKYDLIWICDSGIRVIPDTLTDMVNQMTEKVGLVHGLPYVADRQGF
AATLEQVYFGTSHPRYYISANVTGFKCVTGMSCLMRKDVLDQAGGLIAFAQYIAEDYFMA
KAIADRGWRFAMSTQVAMQNSGSYSISQFQSRMIRWTKLRINMLPATIICEPISECFVAS
LIIGWAAHHVFRWDIMVFFMCHCLAWFIFDYIQLRGVQGGTLCFSKLDYAVAWFIRESMT
IYIFLSALWDPTISWRTGRYRLRCGGTAEEILDV
Blast this sequence in BindingDB or PDB
  Blast E-value cutoff:
BDBM50356076
n/a
NameBDBM50356076
Synonyms:CHEMBL1911817
TypeSmall organic molecule
Emp. Form.C28H28ClF3N4O4
Mol. Mass.576.995
SMILESCN1CCN(CC1)C(=O)[C@@H](COCc1ccccc1)NC(=O)c1cccnc1Oc1ccc(cc1Cl)C(F)(F)F |r|
Structure
Search PDB for entries with ligand similarity:Similarity to this molecule at least: