| Reaction Details |
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 | Report a problem with these data |
| Target | Collagenase 3 |
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| Ligand | BDBM24047 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_774908 (CHEMBL1913353) |
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| IC50 | 4±n/a nM |
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| Citation |  Hu, Y; Xing, L; Thomason, JR; Xiang, J; Ipek, M; Guler, S; Li, H; Sabatini, J; Chockalingam, P; Reifenberg, E; Sheldon, R; Morris, EA; Georgiadis, KE; Tam, S Continued exploration of biphenylsulfonamide scaffold as a platform for aggrecanase-1 inhibition. Bioorg Med Chem Lett21:6800-3 (2011) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Collagenase 3 |
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| Name: | Collagenase 3 |
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| Synonyms: | MMP-13 | MMP13 | MMP13_HUMAN | Matrix metalloproteinase-13 | Matrix metalloproteinase-13 (MMP-13) | Matrix metalloproteinase-13 (MMP13) |
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| Type: | Enzyme |
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| Mol. Mass.: | 53808.06 |
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| Organism: | Homo sapiens (Human) |
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| Description: | P45452 |
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| Residue: | 471 |
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| Sequence: | MHPGVLAAFLFLSWTHCRALPLPSGGDEDDLSEEDLQFAERYLRSYYHPTNLAGILKENA
ASSMTERLREMQSFFGLEVTGKLDDNTLDVMKKPRCGVPDVGEYNVFPRTLKWSKMNLTY
RIVNYTPDMTHSEVEKAFKKAFKVWSDVTPLNFTRLHDGIADIMISFGIKEHGDFYPFDG
PSGLLAHAFPPGPNYGGDAHFDDDETWTSSSKGYNLFLVAAHEFGHSLGLDHSKDPGALM
FPIYTYTGKSHFMLPDDDVQGIQSLYGPGDEDPNPKHPKTPDKCDPSLSLDAITSLRGET
MIFKDRFFWRLHPQQVDAELFLTKSFWPELPNRIDAAYEHPSHDLIFIFRGRKFWALNGY
DILEGYPKKISELGLPKEVKKISAAVHFEDTGKTLLFSGNQVWRYDDTNHIMDKDYPRLI
EEDFPGIGDKVDAVYEKNGYIYFFNGPIQFEYSIWSNRIVRVMPANSILWC
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| BDBM24047 |
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| n/a |
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| Name | BDBM24047 |
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| Synonyms: | (2R)-3-methyl-2-[(4-{4-[(3-methyl-1-benzofuran-2-yl)methoxy]phenyl}benzene)sulfonamido]butanoic acid | biphenylsulfonamide carboxylate, 24 |
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| Type | Small organic molecule |
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| Emp. Form. | C27H27NO6S |
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| Mol. Mass. | 493.571 |
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| SMILES | CC(C)[C@@H](NS(=O)(=O)c1ccc(cc1)-c1ccc(OCc2oc3ccccc3c2C)cc1)C(O)=O |r| |
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| Structure | 
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