Search and Browse
Download
Enter Data
| Reaction Details | |||
|---|---|---|---|
 | Report a problem with these data | ||
| Target | Sphingosine 1-phosphate receptor 4 | ||
| Ligand | BDBM50356264 | ||
| Substrate/Competitor | n/a | ||
| Meas. Tech. | ChEMBL_774916 (CHEMBL1913361) | ||
| EC50 | 104±n/a nM | ||
| Citation |  Urbano, M; Guerrero, M; Velaparthi, S; Crisp, M; Chase, P; Hodder, P; Schaeffer, MT; Brown, S; Rosen, H; Roberts, E Discovery, synthesis and SAR analysis of novel selective small molecule S1P4-R agonists based on a (2Z,5Z)-5-((pyrrol-3-yl)methylene)-3-alkyl-2-(alkylimino)thiazolidin-4-one chemotype. Bioorg Med Chem Lett21:6739-45 (2011) [PubMed] Article | ||
| More Info.: | Get all data from this article, Assay Method | ||
| Sphingosine 1-phosphate receptor 4 | |||
| Name: | Sphingosine 1-phosphate receptor 4 | ||
| Synonyms: | EDG6 | Endothelial differentiation G-protein coupled receptor 6 | S1P receptor 4 | S1P receptor Edg-6 | S1P4 | S1PR4 | S1PR4_HUMAN | Sphingosine 1-phosphate receptor | Sphingosine 1-phosphate receptor Edg-6 | Sphingosine-1-phosphate receptor 4 | sphingosine-1-phosphate 4 S1P4 | ||
| Type: | G Protein-Coupled Receptor (GPCR) | ||
| Mol. Mass.: | 41647.39 | ||
| Organism: | Homo sapiens (Human) | ||
| Description: | n/a | ||
| Residue: | 384 | ||
| Sequence: |
| ||
| BDBM50356264 | |||
| n/a | |||
| Name | BDBM50356264 | ||
| Synonyms: | CHEMBL1910800 | ||
| Type | Small organic molecule | ||
| Emp. Form. | C20H21F2N3OS | ||
| Mol. Mass. | 389.462 | ||
| SMILES | CC\N=C1/S\C(=C/c2cc(C)n(c2C)-c2ccc(F)cc2F)C(=O)N1CC |(23.57,-28.17,;24.34,-29.51,;25.88,-29.51,;26.8,-30.75,;26.33,-32.22,;27.58,-33.13,;27.6,-34.67,;26.27,-35.44,;24.73,-35.45,;24.26,-36.91,;22.79,-37.39,;25.51,-37.82,;26.75,-36.91,;28.08,-37.68,;25.51,-39.36,;24.18,-40.13,;24.19,-41.66,;25.52,-42.43,;25.53,-43.97,;26.86,-41.65,;26.85,-40.11,;28.18,-39.33,;28.82,-32.2,;30.29,-32.66,;28.34,-30.74,;29.23,-29.49,;30.77,-29.49,)| | ||
| Structure | 
| ||