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TargetCalcitonin gene-related peptide (CGRP alpha)
LigandBDBM50224431
Substrate/Competitorn/a
Meas. Tech.ChEMBL_775006
Ki 0.780000±n/a nM
Citation Zartman CBBell IMGallicchio SNGraham SLKane SAMallee JJRutledge RZSalvatore CAVacca JPWilliams TM Identification of a novel RAMP-independent CGRP receptor antagonist. Bioorg Med Chem Lett 21:6705-8 (2011) [PubMed]  Article
More Info.:Get all data from this article,  Assay Method
 
Calcitonin gene-related peptide (CGRP alpha)
Name:Calcitonin gene-related peptide (CGRP alpha)
Synonyms:CGRP | Calcitonin gene-related peptide 1
Type:Enzyme
Mol. Mass.:13902.80
Organism:Homo sapiens (Human)
Description:P06881
Residue:128
Sequence:
MGFQKFSPFLALSILVLLQAGSLHAAPFRSALESSPADPATLSEDEARLLLAALVQNYVQ
MKASELEQEQEREGSRIIAQKRACDTATCVTHRLAGLLSRSGGVVKNNFVPTNVGSKAFG
RRRRDLQA
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  Blast E-value cutoff:
BDBM50224431
n/a
NameBDBM50224431
Synonyms:CHEMBL236593 | MK-0974 | N-[(3R,6S)-6-(2,3-difluorophenyl)-2-oxo-1-(2,2,2-trifluoroethyl)azepan-3-yl]-4-(2-oxo-2,3-dihydro-1H-imidazo[4,5-b]pyridin-1-yl)piperidine-1-carboxamide | Telcagepant
TypeSmall organic molecule
Emp. Form.C26H27F5N6O3
Mol. Mass.566.523
SMILESFc1cccc([C@@H]2CC[C@@H](NC(=O)N3CCC(CC3)n3c4cccnc4[nH]c3=O)C(=O)N(CC(F)(F)F)C2)c1F
Structure
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