| Reaction Details |
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 | Report a problem with these data |
| Target | Calcitonin gene-related peptide 1 |
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| Ligand | BDBM50224431 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_775100 (CHEMBL1912359) |
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| Ki | 1200±n/a nM |
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| Citation |  Zartman, CB; Bell, IM; Gallicchio, SN; Graham, SL; Kane, SA; Mallee, JJ; Rutledge, RZ; Salvatore, CA; Vacca, JP; Williams, TM Identification of a novel RAMP-independent CGRP receptor antagonist. Bioorg Med Chem Lett21:6705-8 (2011) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Calcitonin gene-related peptide 1 |
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| Name: | Calcitonin gene-related peptide 1 |
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| Synonyms: | CALCA_RAT | CGRP | Calc | Calca | Calcitonin gene-related peptide 1 |
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| Type: | Enzyme Catalytic Domain |
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| Mol. Mass.: | 13950.43 |
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| Organism: | RAT |
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| Description: | CGRP 0 RAT::P01256 |
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| Residue: | 128 |
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| Sequence: | MGFLKFSPFLVVSILLLYQACGLQAVPLRSTLESSPGMAATLSEEEARLLLAALVQNYMQ
MKVRELEQEQEAEGSSVTAQKRSCNTATCVTHRLAGLLSRSGGVVKDNFVPTNVGSEAFG
RRRRDLQA
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| BDBM50224431 |
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| n/a |
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| Name | BDBM50224431 |
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| Synonyms: | CHEMBL236593 | MK-0974 | N-[(3R,6S)-6-(2,3-difluorophenyl)-2-oxo-1-(2,2,2-trifluoroethyl)azepan-3-yl]-4-(2-oxo-2,3-dihydro-1H-imidazo[4,5-b]pyridin-1-yl)piperidine-1-carboxamide | Telcagepant |
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| Type | Small organic molecule |
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| Emp. Form. | C26H27F5N6O3 |
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| Mol. Mass. | 566.523 |
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| SMILES | Fc1cccc([C@@H]2CC[C@@H](NC(=O)N3CCC(CC3)n3c4cccnc4[nH]c3=O)C(=O)N(CC(F)(F)F)C2)c1F |
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| Structure | 
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