Reaction Details | |||
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Target | Neuronal acetylcholine receptor subunit alpha-7 | ||
Ligand | BDBM50356472 | ||
Substrate/Competitor | n/a | ||
Meas. Tech. | ChEMBL_775797 (CHEMBL1912300) | ||
Ki | 120±n/a nM | ||
Citation | Kombo, DC; Mazurov, A; Tallapragada, K; Hammond, PS; Chewning, J; Hauser, TA; Vasquez-Valdivieso, M; Yohannes, D; Talley, TT; Taylor, P; Caldwell, WS Docking studies of benzylidene anabaseine interactions witha7 nicotinic acetylcholine receptor (nAChR) and acetylcholine binding proteins (AChBPs): application to the design of relateda7 selective ligands. Eur J Med Chem46:5625-35 (2011) [PubMed] Article | ||
More Info.: | Get all data from this article, Assay Method | ||
Neuronal acetylcholine receptor subunit alpha-7 | |||
Name: | Neuronal acetylcholine receptor subunit alpha-7 | ||
Synonyms: | ACHA7_RAT | Acra7 | Cholinergic, Nicotinic Alpha7 | Cholinergic, Nicotinic Alpha7/5-HT3 | Chrna7 | Neuronal acetylcholine receptor | Neuronal acetylcholine receptor (alpha7 nAChR) | Neuronal acetylcholine receptor subunit alpha 7 | Neuronal acetylcholine receptor subunit alpha-7 | Neuronal acetylcholine receptor subunit alpha-7 (nAChR alpha7) | Neuronal acetylcholine receptor subunit alpha-7 (nAChR) | ||
Type: | Enzyme | ||
Mol. Mass.: | 56502.44 | ||
Organism: | Rattus norvegicus (Rat) | ||
Description: | Q05941 | ||
Residue: | 502 | ||
Sequence: |
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BDBM50356472 | |||
n/a | |||
Name | BDBM50356472 | ||
Synonyms: | CHEMBL1911862 | ||
Type | Small organic molecule | ||
Emp. Form. | C17H20N4O | ||
Mol. Mass. | 296.3669 | ||
SMILES | Nc1c(oc2ccccc12)C1=NC2(CN1)CN1CCC2CC1 |t:12,(17.47,-38.07,;17.87,-36.58,;16.89,-35.39,;17.73,-34.09,;19.22,-34.49,;20.51,-33.66,;21.87,-34.35,;21.96,-35.9,;20.66,-36.73,;19.3,-36.03,;15.35,-35.48,;14.51,-36.77,;13.03,-36.37,;12.95,-34.83,;14.38,-34.28,;13.03,-37.92,;11.7,-38.68,;10.37,-37.92,;10.37,-36.38,;11.7,-35.6,;12.45,-36.93,;11.11,-37.69,)| | ||
Structure |