| Reaction Details |
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 | Report a problem with these data |
| Target | Sodium-dependent serotonin transporter |
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| Ligand | BDBM50356627 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_785531 (CHEMBL1920094) |
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| Ki | 11±n/a nM |
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| Citation |  Liu, J; Zhu, L; Plössl, K; Lieberman, BP; Kung, HF Synthesis and evaluation of novel N-fluoropyridyl derivatives of tropane as potential PET imaging agents for the dopamine transporter. Bioorg Med Chem Lett21:2962-5 (2011) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Sodium-dependent serotonin transporter |
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| Name: | Sodium-dependent serotonin transporter |
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| Synonyms: | 5-HT Transporter | 5HT transporter | 5HTT | HTT | SC6A4_HUMAN | SERT | SLC6A4 | Serotonin Transporter (SERT) | Serotonin transporter (5HTT) | Serotonin transporter protein (SERT) | Sodium-dependent serotonin transporter (SERT) | Solute carrier family 6 member 4 |
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| Type: | Multi-pass membrane protein |
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| Mol. Mass.: | 70322.51 |
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| Organism: | Homo sapiens (Human) |
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| Description: | P31645 |
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| Residue: | 630 |
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| Sequence: | METTPLNSQKQLSACEDGEDCQENGVLQKVVPTPGDKVESGQISNGYSAVPSPGAGDDTR
HSIPATTTTLVAELHQGERETWGKKVDFLLSVIGYAVDLGNVWRFPYICYQNGGGAFLLP
YTIMAIFGGIPLFYMELALGQYHRNGCISIWRKICPIFKGIGYAICIIAFYIASYYNTIM
AWALYYLISSFTDQLPWTSCKNSWNTGNCTNYFSEDNITWTLHSTSPAEEFYTRHVLQIH
RSKGLQDLGGISWQLALCIMLIFTVIYFSIWKGVKTSGKVVWVTATFPYIILSVLLVRGA
TLPGAWRGVLFYLKPNWQKLLETGVWIDAAAQIFFSLGPGFGVLLAFASYNKFNNNCYQD
ALVTSVVNCMTSFVSGFVIFTVLGYMAEMRNEDVSEVAKDAGPSLLFITYAEAIANMPAS
TFFAIIFFLMLITLGLDSTFAGLEGVITAVLDEFPHVWAKRRERFVLAVVITCFFGSLVT
LTFGGAYVVKLLEEYATGPAVLTVALIEAVAVSWFYGITQFCRDVKEMLGFSPGWFWRIC
WVAISPLFLLFIICSFLMSPPQLRLFQYNYPYWSIILGYCIGTSSFICIPTYIAYRLIIT
PGTFKERIIKSITPETPTEIPCGDIRLNAV
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| BDBM50356627 |
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| n/a |
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| Name | BDBM50356627 |
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| Synonyms: | CHEMBL1914698 |
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| Type | Small organic molecule |
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| Emp. Form. | C20H23BrClN3 |
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| Mol. Mass. | 420.774 |
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| SMILES | CN1C2CCC1[C@@H](CNc1ccnc(Br)c1)[C@H](C2)c1ccc(Cl)cc1 |r,TLB:0:1:16.6.17:3.4| |
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| Structure | 
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