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TargetProstaglandin D2 receptor 2
LigandBDBM50356739
Substrate/Competitorn/a
Meas. Tech.ChEMBL_785711 (CHEMBL1920639)
Ki 12±n/a nM
Citation Crosignani, SPrêtre, AJorand-Lebrun, CFraboulet, GSeenisamy, JAugustine, JKMissotten, MHumbert, YCleva, CAbla, NDaff, HSchott, OSchneider, MBurgat-Charvillon, FRivron, DHamernig, IArrighi, JFGaudet, MZimmerli, SCJuillard, PJohnson, Z Discovery of potent, selective, and orally bioavailable alkynylphenoxyacetic acid CRTH2 (DP2) receptor antagonists for the treatment of allergic inflammatory diseases. J Med Chem54:7299-317 (2011) [PubMed]  Article
More Info.:Get all data from this article,  Assay Method
 
Prostaglandin D2 receptor 2
Name:Prostaglandin D2 receptor 2
Synonyms:CD_antigen=CD294 | CRTH2 | Chemoattractant Receptor-homologous molecule expressed on T-helper type 2 cells (CRTH2) | Chemoattractant receptor-homologous molecule expressed on Th2 cells | Chemoattractant receptor-homologous molecule expressed on Th2 cells (CRTH2) | DL1R | G protein-coupled receptor 44 | G-protein coupled receptor 44 | GPR44 | PD2R2_HUMAN | PTGDR2 | Prostaglandin D2 | Prostaglandin D2 receptor 2 | Prostaglandin D2 receptor 2 (PGD2)
Type:Enzyme
Mol. Mass.:43295.45
Organism:Homo sapiens (Human)
Description:Q9Y5Y4
Residue:395
Sequence:
MSANATLKPLCPILEQMSRLQSHSNTSIRYIDHAAVLLHGLASLLGLVENGVILFVVGCR
MRQTVVTTWVLHLALSDLLASASLPFFTYFLAVGHSWELGTTFCKLHSSIFFLNMFASGF
LLSAISLDRCLQVVRPVWAQNHRTVAAAHKVCLVLWALAVLNTVPYFVFRDTISRLDGRI
MCYYNVLLLNPGPDRDATCNSRQVALAVSKFLLAFLVPLAIIASSHAAVSLRLQHRGRRR
PGRFVRLVAAVVAAFALCWGPYHVFSLLEARAHANPGLRPLVWRGLPFVTSLAFFNSVAN
PVLYVLTCPDMLRKLRRSLRTVLESVLVDDSELGGAGSSRRRRTSSTARSASPLALCSRP
EEPRGPARLLGWLLGSCAASPQTGPLNRALSSTSS
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  Blast E-value cutoff:
BDBM50356739
n/a
NameBDBM50356739
Synonyms:CHEMBL1917792
TypeSmall organic molecule
Emp. Form.C17H10ClF3O3
Mol. Mass.354.708
SMILESOC(=O)COc1ccc(cc1C#Cc1ccccc1Cl)C(F)(F)F
Structure
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