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TargetHistamine H4 receptor
LigandBDBM50356873
Substrate/Competitorn/a
Meas. Tech.ChEMBL_786095
Ki 0.1±n/a nM
Citation Savall BMGomez LChavez FCurtis MMeduna SPKearney ADunford PCowden JThurmond RLGrice CEdwards JP Tricyclic aminopyrimidine histamine H4 receptor antagonists. Bioorg Med Chem Lett 21:6577-81 (2011) [PubMed]  Article
More Info.:Get all data from this article,  Assay Method
 
Histamine H4 receptor
Name:Histamine H4 receptor
Synonyms:AXOR35 | G-protein coupled receptor 105 | GPRv53 | HH4R | HISTAMINE H4 | Histamine H4 receptor (H4R) | Histamine receptor (H3 and H4) | Pfi-013 | SP9144
Type:G Protein-Coupled Receptor (GPCR)
Mol. Mass.:44517.02
Organism:Homo sapiens (Human)
Description:Binding assays were using CHO cells stably expressing hH4R receptors.
Residue:390
Sequence:
MPDTNSTINLSLSTRVTLAFFMSLVAFAIMLGNALVILAFVVDKNLRHRSSYFFLNLAIS
DFFVGVISIPLYIPHTLFEWDFGKEICVFWLTTDYLLCTASVYNIVLISYDRYLSVSNAV
SYRTQHTGVLKIVTLMVAVWVLAFLVNGPMILVSESWKDEGSECEPGFFSEWYILAITSF
LEFVIPVILVAYFNMNIYWSLWKRDHLSRCQSHPGLTAVSSNICGHSFRGRLSSRRSLSA
STEVPASFHSERQRRKSSLMFSSRTKMNSNTIASKMGSFSQSDSVALHQREHVELLRARR
LAKSLAILLGVFAVCWAPYSLFTIVLSFYSSATGPKSVWYRIAFWLQWFNSFVNPLLYPL
CHKRFQKAFLKIFCIKKQPLPSQHSRSVSS
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BDBM50356873
n/a
NameBDBM50356873
Synonyms:CHEMBL1914541
TypeSmall organic molecule
Emp. Form.C15H16ClN5O
Mol. Mass.317.773
SMILESCN1CCN(CC1)c1nc(N)nc2c3cc(Cl)ccc3oc12
Structure
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