| Reaction Details |
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 | Report a problem with these data |
| Target | Histamine receptor H4 |
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| Ligand | BDBM22566 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_785248 (CHEMBL1921329) |
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| Ki | 1071.52±n/a nM |
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| Citation |  Mowbray, CE; Bell, AS; Clarke, NP; Collins, M; Jones, RM; Lane, CA; Liu, WL; Newman, SD; Paradowski, M; Schenck, EJ; Selby, MD; Swain, NA; Williams, DH Challenges of drug discovery in novel target space. The discovery and evaluation of PF-3893787: a novel histamine H4 receptor antagonist. Bioorg Med Chem Lett21:6596-602 (2011) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Histamine receptor H4 |
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| Name: | Histamine receptor H4 |
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| Synonyms: | HISTAMINE H4 | HRH4 | Histamine H4 receptor |
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| Type: | Enzyme Catalytic Domain |
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| Mol. Mass.: | 44536.99 |
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| Organism: | GUINEA PIG |
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| Description: | HISTAMINE H4 HRH4 GUINEA PIG::Q91ZY3 |
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| Residue: | 389 |
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| Sequence: | MLANNSTIALTSIKISLTFLMSLLAIAIMLGNVVVILAFIVDRNLRHRSNYFFLNLAIAD
FFVGAIAIPLYIPSSLTYWTSGKQACVFWLITDYLLCTASVYNIVLISYDRYQSVSNAVW
YRAQHSGTWKIATQMVAVWIFSFMTNGPMILISDSWQNSTTECEPGFLKKWYFALPTSLL
EFLIPILLVAYFSAHIYWSLWKREKLSRCLSHPVLPSDSSSSDHGHSCRQDPDSRATLPA
RKETTASLGSDKSRRKSSLLFSIRAYKNSNVIASKMGFLSHSDSLALQQREHIELFRARK
LAKSLAILLAAFAICWAPYSLTTVIYSFFPERNLTKSTWYHTAFWLQWFNSFVNPFLYPL
CHKRFQKAFLKILPVRRQSTPPHNRSIST
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| BDBM22566 |
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| n/a |
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| Name | BDBM22566 |
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| Synonyms: | 5-chloro-2-[(4-methylpiperazin-1-yl)carbonyl]-1H-indole | CHEMBL129198 | JNJ 7777120 |
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| Type | Small organic molecule |
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| Emp. Form. | C14H16ClN3O |
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| Mol. Mass. | 277.749 |
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| SMILES | CN1CCN(CC1)C(=O)c1cc2cc(Cl)ccc2[nH]1 |
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| Structure | 
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