| Reaction Details |
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 | Report a problem with these data |
| Target | Histamine H4 receptor |
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| Ligand | BDBM50356884 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_785250 (CHEMBL1921331) |
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| Ki | 20.89±n/a nM |
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| Citation |  Mowbray, CE; Bell, AS; Clarke, NP; Collins, M; Jones, RM; Lane, CA; Liu, WL; Newman, SD; Paradowski, M; Schenck, EJ; Selby, MD; Swain, NA; Williams, DH Challenges of drug discovery in novel target space. The discovery and evaluation of PF-3893787: a novel histamine H4 receptor antagonist. Bioorg Med Chem Lett21:6596-602 (2011) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Histamine H4 receptor |
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| Name: | Histamine H4 receptor |
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| Synonyms: | HH4R | HRH4_MOUSE | Hrh4 |
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| Type: | G Protein-Coupled Receptor (GPCR) |
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| Mol. Mass.: | 44272.75 |
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| Organism: | Mus musculus (mouse) |
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| Description: | Cell pellets from SK-N-MC cells transfected with mouse H4 receptor were used in binding assay. |
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| Residue: | 391 |
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| Sequence: | MSESNSTGILPPAAQVPLAFLMSSFAFAIMVGNAVVILAFVVDRNLRHRSNYFFLNLAIS
DFLVGLISIPLYIPHVLFNWNFGSGICMFWLITDYLLCTASVYNIVLISYDRYQSVSNAV
SYRAQHTGIMKIVAQMVAVWILAFLVNGPMILASDSWKNSTNTKDCEPGFVTEWYILTIT
MLLEFLLPVISVAYFNVQIYWSLWKRRALSRCPSHAGFSTTSSSASGHLHRAGVACRTSN
PGLKESAASRHSESPRRKSSILVSLRTHMNSSITAFKVGSFWRSESAALRQREYAELLRG
RKLARSLAILLSAFAICWAPYCLFTIVLSTYPRTERPKSVWYSIAFWLQWFNSFVNPFLY
PLCHRRFQKAFWKILCVTKQPALSQNQSVSS
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| BDBM50356884 |
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| n/a |
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| Name | BDBM50356884 |
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| Synonyms: | CHEMBL1915540 |
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| Type | Small organic molecule |
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| Emp. Form. | C13H22N6 |
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| Mol. Mass. | 262.354 |
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| SMILES | CN[C@@H]1CCN(C1)c1cc(NCC2CC2)nc(N)n1 |r| |
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| Structure | 
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