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| Reaction Details | |||
|---|---|---|---|
 | Report a problem with these data | ||
| Target | Androgen receptor | ||
| Ligand | BDBM50356981 | ||
| Substrate/Competitor | n/a | ||
| Meas. Tech. | ChEMBL_788156 (CHEMBL1919237) | ||
| IC50 | 70±n/a nM | ||
| Citation |  Guo, C; Linton, A; Kephart, S; Ornelas, M; Pairish, M; Gonzalez, J; Greasley, S; Nagata, A; Burke, BJ; Edwards, M; Hosea, N; Kang, P; Hu, W; Engebretsen, J; Briere, D; Shi, M; Gukasyan, H; Richardson, P; Dack, K; Underwood, T; Johnson, P; Morell, A; Felstead, R; Kuruma, H; Matsimoto, H; Zoubeidi, A; Gleave, M; Los, G; Fanjul, AN Discovery of aryloxy tetramethylcyclobutanes as novel androgen receptor antagonists. J Med Chem54:7693-704 (2011) [PubMed] Article | ||
| More Info.: | Get all data from this article, Assay Method | ||
| Androgen receptor | |||
| Name: | Androgen receptor | ||
| Synonyms: | ANDR_HUMAN | AR | Androgen Receptor | Androgen receptor (AR) | Androgen receptor/Baculoviral IAP repeat-containing protein 2 | DHTR | Dihydrotestosterone receptor | NR3C4 | Nuclear receptor subfamily 3 group C member 4 | ||
| Type: | Receptor | ||
| Mol. Mass.: | 99185.27 | ||
| Organism: | Homo sapiens (Human) | ||
| Description: | CHO cells were stably transfected with human AR gene. | ||
| Residue: | 920 | ||
| Sequence: |
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| BDBM50356981 | |||
| n/a | |||
| Name | BDBM50356981 | ||
| Synonyms: | CHEMBL1916238 | ||
| Type | Small organic molecule | ||
| Emp. Form. | C18H24N2O2 | ||
| Mol. Mass. | 300.3954 | ||
| SMILES | CC(=O)N[C@H]1C(C)(C)[C@H](Oc2ccc(C#N)c(C)c2)C1(C)C |r,wU:4.3,wD:8.8,(19.82,-7.76,;18.47,-7.01,;17.15,-7.81,;18.44,-5.47,;17.09,-4.73,;15.55,-4.73,;15.14,-6.21,;14.05,-5.12,;15.55,-3.19,;14.22,-2.41,;14.22,-.87,;12.89,-.11,;12.89,1.43,;14.23,2.2,;14.24,3.74,;14.24,5.27,;15.56,1.42,;16.9,2.19,;15.56,-.11,;17.09,-3.19,;17.48,-1.69,;18.57,-3.58,)| | ||
| Structure | 
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