Reaction Details | |||
---|---|---|---|
Report a problem with these data | |||
Target | Androgen receptor | ||
Ligand | BDBM50356992 | ||
Substrate/Competitor | n/a | ||
Meas. Tech. | ChEMBL_788156 (CHEMBL1919237) | ||
IC50 | 69±n/a nM | ||
Citation | Guo, C; Linton, A; Kephart, S; Ornelas, M; Pairish, M; Gonzalez, J; Greasley, S; Nagata, A; Burke, BJ; Edwards, M; Hosea, N; Kang, P; Hu, W; Engebretsen, J; Briere, D; Shi, M; Gukasyan, H; Richardson, P; Dack, K; Underwood, T; Johnson, P; Morell, A; Felstead, R; Kuruma, H; Matsimoto, H; Zoubeidi, A; Gleave, M; Los, G; Fanjul, AN Discovery of aryloxy tetramethylcyclobutanes as novel androgen receptor antagonists. J Med Chem54:7693-704 (2011) [PubMed] Article | ||
More Info.: | Get all data from this article, Assay Method | ||
Androgen receptor | |||
Name: | Androgen receptor | ||
Synonyms: | ANDR_HUMAN | AR | Androgen Receptor | Androgen receptor (AR) | Androgen receptor/Baculoviral IAP repeat-containing protein 2 | DHTR | Dihydrotestosterone receptor | NR3C4 | Nuclear receptor subfamily 3 group C member 4 | ||
Type: | Receptor | ||
Mol. Mass.: | 99185.27 | ||
Organism: | Homo sapiens (Human) | ||
Description: | CHO cells were stably transfected with human AR gene. | ||
Residue: | 920 | ||
Sequence: |
| ||
BDBM50356992 | |||
n/a | |||
Name | BDBM50356992 | ||
Synonyms: | CHEMBL1916248 | ||
Type | Small organic molecule | ||
Emp. Form. | C23H24ClN5O2 | ||
Mol. Mass. | 437.922 | ||
SMILES | Cc1nc2ncccn2c1C(=O)N[C@H]1C(C)(C)[C@H](Oc2ccc(C#N)c(Cl)c2)C1(C)C |r,wU:13.14,wD:17.19,(22.86,-40.64,;23.98,-39.59,;25.49,-39.88,;26.24,-38.53,;27.73,-38.19,;28.18,-36.72,;27.13,-35.59,;25.63,-35.94,;25.19,-37.41,;23.79,-38.07,;22.44,-37.32,;21.12,-38.12,;22.41,-35.78,;21.06,-35.04,;19.52,-35.04,;19.11,-36.52,;18.02,-35.43,;19.52,-33.5,;18.19,-32.72,;18.2,-31.18,;16.87,-30.42,;16.87,-28.88,;18.21,-28.11,;18.21,-26.57,;18.22,-25.04,;19.54,-28.89,;20.87,-28.12,;19.53,-30.42,;21.06,-33.5,;21.45,-32,;22.54,-33.89,)| | ||
Structure |