Reaction Details | |||
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Target | Androgen receptor | ||
Ligand | BDBM50356993 | ||
Substrate/Competitor | n/a | ||
Meas. Tech. | ChEMBL_788156 (CHEMBL1919237) | ||
IC50 | 136±n/a nM | ||
Citation | Guo, C; Linton, A; Kephart, S; Ornelas, M; Pairish, M; Gonzalez, J; Greasley, S; Nagata, A; Burke, BJ; Edwards, M; Hosea, N; Kang, P; Hu, W; Engebretsen, J; Briere, D; Shi, M; Gukasyan, H; Richardson, P; Dack, K; Underwood, T; Johnson, P; Morell, A; Felstead, R; Kuruma, H; Matsimoto, H; Zoubeidi, A; Gleave, M; Los, G; Fanjul, AN Discovery of aryloxy tetramethylcyclobutanes as novel androgen receptor antagonists. J Med Chem54:7693-704 (2011) [PubMed] Article | ||
More Info.: | Get all data from this article, Assay Method | ||
Androgen receptor | |||
Name: | Androgen receptor | ||
Synonyms: | ANDR_HUMAN | AR | Androgen Receptor | Androgen receptor (AR) | Androgen receptor/Baculoviral IAP repeat-containing protein 2 | DHTR | Dihydrotestosterone receptor | NR3C4 | Nuclear receptor subfamily 3 group C member 4 | ||
Type: | Receptor | ||
Mol. Mass.: | 99185.27 | ||
Organism: | Homo sapiens (Human) | ||
Description: | CHO cells were stably transfected with human AR gene. | ||
Residue: | 920 | ||
Sequence: |
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BDBM50356993 | |||
n/a | |||
Name | BDBM50356993 | ||
Synonyms: | CHEMBL1916249 | ||
Type | Small organic molecule | ||
Emp. Form. | C22H27ClN4O3 | ||
Mol. Mass. | 430.928 | ||
SMILES | COCCn1ccc(n1)C(=O)N[C@H]1C(C)(C)[C@H](Oc2ccc(C#N)c(Cl)c2)C1(C)C |r,wU:12.12,wD:16.17,(43.88,-41.99,;43.1,-40.67,;41.56,-40.68,;40.78,-39.36,;39.24,-39.37,;38.34,-40.63,;36.87,-40.17,;36.86,-38.63,;38.32,-38.14,;35.51,-37.89,;34.19,-38.69,;35.48,-36.35,;34.13,-35.61,;32.59,-35.61,;32.18,-37.08,;31.09,-36,;32.59,-34.06,;31.26,-33.29,;31.26,-31.75,;29.93,-30.99,;29.93,-29.45,;31.27,-28.68,;31.28,-27.14,;31.28,-25.61,;32.6,-29.45,;33.94,-28.69,;32.6,-30.99,;34.13,-34.07,;34.52,-32.57,;35.61,-34.46,)| | ||
Structure |