| Reaction Details |
|---|
 | Report a problem with these data |
| Target | Collagenase 3 |
|---|
| Ligand | BDBM50357029 |
|---|
| Substrate/Competitor | n/a |
|---|
| Meas. Tech. | ChEMBL_788431 (CHEMBL1918196) |
|---|
| IC50 | 0.6±n/a nM |
|---|
| Citation |  Tommasi, RA; Weiler, S; McQuire, LW; Rogel, O; Chambers, M; Clark, K; Doughty, J; Fang, J; Ganu, V; Grob, J; Goldberg, R; Goldstein, R; Lavoie, S; Kulathila, R; Macchia, W; Melton, R; Springer, C; Walker, M; Zhang, J; Zhu, L; Shultz, M Potent and selective 2-naphthylsulfonamide substituted hydroxamic acid inhibitors of matrix metalloproteinase-13. Bioorg Med Chem Lett21:6440-5 (2011) [PubMed] Article |
|---|
| More Info.: | Get all data from this article, Assay Method |
|---|
| |
| Collagenase 3 |
|---|
| Name: | Collagenase 3 |
|---|
| Synonyms: | MMP-13 | MMP13 | MMP13_HUMAN | Matrix metalloproteinase-13 | Matrix metalloproteinase-13 (MMP-13) | Matrix metalloproteinase-13 (MMP13) |
|---|
| Type: | Enzyme |
|---|
| Mol. Mass.: | 53808.06 |
|---|
| Organism: | Homo sapiens (Human) |
|---|
| Description: | P45452 |
|---|
| Residue: | 471 |
|---|
| Sequence: | MHPGVLAAFLFLSWTHCRALPLPSGGDEDDLSEEDLQFAERYLRSYYHPTNLAGILKENA
ASSMTERLREMQSFFGLEVTGKLDDNTLDVMKKPRCGVPDVGEYNVFPRTLKWSKMNLTY
RIVNYTPDMTHSEVEKAFKKAFKVWSDVTPLNFTRLHDGIADIMISFGIKEHGDFYPFDG
PSGLLAHAFPPGPNYGGDAHFDDDETWTSSSKGYNLFLVAAHEFGHSLGLDHSKDPGALM
FPIYTYTGKSHFMLPDDDVQGIQSLYGPGDEDPNPKHPKTPDKCDPSLSLDAITSLRGET
MIFKDRFFWRLHPQQVDAELFLTKSFWPELPNRIDAAYEHPSHDLIFIFRGRKFWALNGY
DILEGYPKKISELGLPKEVKKISAAVHFEDTGKTLLFSGNQVWRYDDTNHIMDKDYPRLI
EEDFPGIGDKVDAVYEKNGYIYFFNGPIQFEYSIWSNRIVRVMPANSILWC
|
|
|
|---|
| BDBM50357029 |
|---|
| n/a |
|---|
| Name | BDBM50357029 |
|---|
| Synonyms: | CHEMBL1916653 |
|---|
| Type | Small organic molecule |
|---|
| Emp. Form. | C21H30N2O4S |
|---|
| Mol. Mass. | 406.539 |
|---|
| SMILES | CC(C)CCN([C@H](CC(C)C)C(=O)NO)S(=O)(=O)c1ccc2ccccc2c1 |r| |
|---|
| Structure | 
|
|---|
Search and Browse
