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TargetcGMP-specific 3',5'-cyclic phosphodiesterase
LigandBDBM50357263
Substrate/Competitorn/a
Meas. Tech.ChEMBL_788276
IC50 0.050000±n/a nM
Citation Hughes ROMaddux TJoseph Rogier DLu SWalker JKJon Jacobsen ERumsey JMZheng YMacinnes ABond BRHan S Investigation of the pyrazinones as PDE5 inhibitors: evaluation of regioisomeric projections into the solvent region. Bioorg Med Chem Lett 21:6348-52 (2011) [PubMed]  Article
More Info.:Get all data from this article,  Assay Method
 
cGMP-specific 3',5'-cyclic phosphodiesterase
Name:3',5'-cyclic phosphodiesterase
Synonyms:CGB-PDE | PDE5 | PDE5A | Phosphodiesterase 5 (PDE5) | Phosphodiesterase 5A | Phosphodiesterase 5A (PDE5A) | cGMP-binding cGMP-specific phosphodiesterase
Type:Protein
Mol. Mass.:99975.83
Organism:Homo sapiens (Human)
Description:O76074
Residue:875
Sequence:
MERAGPSFGQQRQQQQPQQQKQQQRDQDSVEAWLDDHWDFTFSYFVRKATREMVNAWFAE
RVHTIPVCKEGIRGHTESCSCPLQQSPRADNSAPGTPTRKISASEFDRPLRPIVVKDSEG
TVSFLSDSEKKEQMPLTPPRFDHDEGDQCSRLLELVKDISSHLDVTALCHKIFLHIHGLI
SADRYSLFLVCEDSSNDKFLISRLFDVAEGSTLEEVSNNCIRLEWNKGIVGHVAALGEPL
NIKDAYEDPRFNAEVDQITGYKTQSILCMPIKNHREEVVGVAQAINKKSGNGGTFTEKDE
KDFAAYLAFCGIVLHNAQLYETSLLENKRNQVLLDLASLIFEEQQSLEVILKKIAATIIS
FMQVQKCTIFIVDEDCSDSFSSVFHMECEELEKSSDTLTREHDANKINYMYAQYVKNTME
PLNIPDVSKDKRFPWTTENTGNVNQQCIRSLLCTPIKNGKKNKVIGVCQLVNKMEENTGK
VKPFNRNDEQFLEAFVIFCGLGIQNTQMYEAVERAMAKQMVTLEVLSYHASAAEEETREL
QSLAAAVVPSAQTLKITDFSFSDFELSDLETALCTIRMFTDLNLVQNFQMKHEVLCRWIL
SVKKNYRKNVAYHNWRHAFNTAQCMFAALKAGKIQNKLTDLEILALLIAALSHDLDHRGV
NNSYIQRSEHPLAQLYCHSIMEHHHFDQCLMILNSPGNQILSGLSIEEYKTTLKIIKQAI
LATDLALYIKRRGEFFELIRKNQFNLEDPHQKELFLAMLMTACDLSAITKPWPIQQRIAE
LVATEFFDQGDRERKELNIEPTDLMNREKKNKIPSMQVGFIDAICLQLYEALTHVSEDCF
PLLDGCRKNRQKWQALAEQQEKMLINGESGQAKRN
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  Blast E-value cutoff:
BDBM50357263
n/a
NameBDBM50357263
Synonyms:CHEMBL1916293
TypeSmall organic molecule
Emp. Form.C24H31N5O4
Mol. Mass.453.534
SMILESCCCOCCn1c2cc(ncc2c(NC2CCC(O)CC2)nc1=O)-c1ccc(OC)nc1 |(28.17,-7.71,;26.83,-8.48,;25.5,-7.71,;24.17,-8.48,;24.17,-10.02,;22.83,-10.79,;22.83,-12.33,;24.16,-13.11,;25.48,-12.34,;26.81,-13.1,;26.82,-14.65,;25.49,-15.41,;24.16,-14.65,;22.83,-15.41,;22.83,-16.95,;21.5,-17.72,;20.17,-16.95,;18.84,-17.71,;18.84,-19.25,;17.5,-20.02,;20.17,-20.02,;21.51,-19.26,;21.5,-14.65,;21.5,-13.11,;20.17,-12.34,;28.14,-12.33,;28.13,-10.79,;29.46,-10.01,;30.8,-10.78,;32.13,-10,;33.47,-10.77,;30.81,-12.32,;29.48,-13.1,)|
Structure
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