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TargetcGMP-specific 3',5'-cyclic phosphodiesterase
LigandBDBM50357240
Substrate/Competitorn/a
Meas. Tech.ChEMBL_788276
IC50 0.020000±n/a nM
Citation Hughes ROMaddux TJoseph Rogier DLu SWalker JKJon Jacobsen ERumsey JMZheng YMacinnes ABond BRHan S Investigation of the pyrazinones as PDE5 inhibitors: evaluation of regioisomeric projections into the solvent region. Bioorg Med Chem Lett 21:6348-52 (2011) [PubMed]  Article
More Info.:Get all data from this article,  Assay Method
 
cGMP-specific 3',5'-cyclic phosphodiesterase
Name:3',5'-cyclic phosphodiesterase
Synonyms:CGB-PDE | PDE5 | PDE5A | Phosphodiesterase 5 (PDE5) | Phosphodiesterase 5A | Phosphodiesterase 5A (PDE5A) | cGMP-binding cGMP-specific phosphodiesterase
Type:Protein
Mol. Mass.:99975.83
Organism:Homo sapiens (Human)
Description:O76074
Residue:875
Sequence:
MERAGPSFGQQRQQQQPQQQKQQQRDQDSVEAWLDDHWDFTFSYFVRKATREMVNAWFAE
RVHTIPVCKEGIRGHTESCSCPLQQSPRADNSAPGTPTRKISASEFDRPLRPIVVKDSEG
TVSFLSDSEKKEQMPLTPPRFDHDEGDQCSRLLELVKDISSHLDVTALCHKIFLHIHGLI
SADRYSLFLVCEDSSNDKFLISRLFDVAEGSTLEEVSNNCIRLEWNKGIVGHVAALGEPL
NIKDAYEDPRFNAEVDQITGYKTQSILCMPIKNHREEVVGVAQAINKKSGNGGTFTEKDE
KDFAAYLAFCGIVLHNAQLYETSLLENKRNQVLLDLASLIFEEQQSLEVILKKIAATIIS
FMQVQKCTIFIVDEDCSDSFSSVFHMECEELEKSSDTLTREHDANKINYMYAQYVKNTME
PLNIPDVSKDKRFPWTTENTGNVNQQCIRSLLCTPIKNGKKNKVIGVCQLVNKMEENTGK
VKPFNRNDEQFLEAFVIFCGLGIQNTQMYEAVERAMAKQMVTLEVLSYHASAAEEETREL
QSLAAAVVPSAQTLKITDFSFSDFELSDLETALCTIRMFTDLNLVQNFQMKHEVLCRWIL
SVKKNYRKNVAYHNWRHAFNTAQCMFAALKAGKIQNKLTDLEILALLIAALSHDLDHRGV
NNSYIQRSEHPLAQLYCHSIMEHHHFDQCLMILNSPGNQILSGLSIEEYKTTLKIIKQAI
LATDLALYIKRRGEFFELIRKNQFNLEDPHQKELFLAMLMTACDLSAITKPWPIQQRIAE
LVATEFFDQGDRERKELNIEPTDLMNREKKNKIPSMQVGFIDAICLQLYEALTHVSEDCF
PLLDGCRKNRQKWQALAEQQEKMLINGESGQAKRN
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  Blast E-value cutoff:
BDBM50357240
n/a
NameBDBM50357240
Synonyms:CHEMBL1916486
TypeSmall organic molecule
Emp. Form.C24H30N6O5
Mol. Mass.482.5322
SMILESCCCOCCn1c2cc(nnc2c(NC2CCC(CC2)C(O)=O)nc1=O)-c1ccc(OC)nc1 |(2.15,6.01,;.82,5.24,;-.51,6.01,;-1.85,5.24,;-1.85,3.69,;-3.18,2.92,;-3.18,1.38,;-1.85,.61,;-.53,1.37,;.8,.61,;.8,-.93,;-.53,-1.7,;-1.86,-.93,;-3.18,-1.7,;-3.18,-3.24,;-4.51,-4.01,;-5.85,-3.24,;-7.18,-4,;-7.18,-5.54,;-5.85,-6.32,;-4.51,-5.55,;-8.52,-6.31,;-9.85,-5.54,;-8.52,-7.85,;-4.51,-.93,;-4.51,.61,;-5.85,1.37,;2.12,1.39,;2.12,2.92,;3.44,3.7,;4.79,2.93,;6.12,3.71,;7.45,2.95,;4.79,1.39,;3.46,.62,)|
Structure
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