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| Reaction Details | |||
|---|---|---|---|
 | Report a problem with these data | ||
| Target | cGMP-inhibited 3',5'-cyclic phosphodiesterase 3B | ||
| Ligand | BDBM50357234 | ||
| Substrate/Competitor | n/a | ||
| Meas. Tech. | ChEMBL_788288 (CHEMBL1919551) | ||
| IC50 | >2000±n/a nM | ||
| Citation |  Hughes, RO; Maddux, T; Joseph Rogier, D; Lu, S; Walker, JK; Jon Jacobsen, E; Rumsey, JM; Zheng, Y; Macinnes, A; Bond, BR; Han, S Investigation of the pyrazinones as PDE5 inhibitors: evaluation of regioisomeric projections into the solvent region. Bioorg Med Chem Lett21:6348-52 (2011) [PubMed] Article | ||
| More Info.: | Get all data from this article, Assay Method | ||
| cGMP-inhibited 3',5'-cyclic phosphodiesterase 3B | |||
| Name: | cGMP-inhibited 3',5'-cyclic phosphodiesterase 3B | ||
| Synonyms: | CGI-PDE B | CGIP1 | CGIPDE1 | Cyclic GMP-inhibited phosphodiesterase B | PDE3B | PDE3B_HUMAN | Phosphodiesterase 3B | Phosphodiesterase 3B (PDE3B) | Phosphodiesterase Type 3 (PDE3B) | cGMP-inhibited 3',5'-cyclic phosphodiesterase B | cGMP-inhibited 3,5-cyclic phosphodiesterase B | ||
| Type: | Enzyme | ||
| Mol. Mass.: | 124318.95 | ||
| Organism: | Homo sapiens (Human) | ||
| Description: | PDE3B was generated from the full-length recombinant human clone transfected into Sf9 cells. | ||
| Residue: | 1112 | ||
| Sequence: |
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| BDBM50357234 | |||
| n/a | |||
| Name | BDBM50357234 | ||
| Synonyms: | CHEMBL1916475 | ||
| Type | Small organic molecule | ||
| Emp. Form. | C23H30N6O4 | ||
| Mol. Mass. | 454.5221 | ||
| SMILES | CCCOCCn1c2cc(nnc2c(NC2CCC(O)CC2)nc1=O)-c1ccc(OC)nc1 |(22.74,-11.54,;21.41,-12.31,;20.07,-11.54,;18.74,-12.31,;18.74,-13.85,;17.41,-14.62,;17.41,-16.16,;18.74,-16.94,;20.06,-16.18,;21.39,-16.94,;21.39,-18.48,;20.06,-19.25,;18.73,-18.48,;17.41,-19.24,;17.41,-20.78,;16.08,-21.56,;14.75,-20.78,;13.42,-21.54,;13.41,-23.08,;12.08,-23.85,;14.75,-23.86,;16.09,-23.09,;16.08,-18.48,;16.08,-16.94,;14.74,-16.18,;22.71,-16.16,;22.71,-14.63,;24.03,-13.85,;25.38,-14.61,;26.71,-13.84,;28.04,-14.6,;25.38,-16.16,;24.05,-16.93,)| | ||
| Structure | 
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