| Reaction Details |
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 | Report a problem with these data |
| Target | Histamine H2 receptor |
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| Ligand | BDBM50356878 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_788363 (CHEMBL1918044) |
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| Ki | 8820±n/a nM |
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| Citation |  Masood, MA; Selby, MD; Bell, AS; Mansfield, AC; Gardner, M; Smith, GF; Lane, C; Kenyon-Edwards, H; Osborne, R; Jones, RM; Liu, WL; Brown, CD; Clarke, N; Perrucio, F; Mowbray, CE Discovery of a series of potent and selective human H4 antagonists using ligand efficiency and libraries to explore structure-activity relationship (SAR). Bioorg Med Chem Lett21:6591-5 (2011) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Histamine H2 receptor |
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| Name: | Histamine H2 receptor |
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| Synonyms: | Gastric receptor I | H2R | HISTAMINE H2 | HRH2 | HRH2_HUMAN | Histamine H2 receptor | Histamine H2-Gs alpha S |
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| Type: | G Protein-Coupled Receptor (GPCR) |
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| Mol. Mass.: | 40115.31 |
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| Organism: | Homo sapiens (Human) |
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| Description: | n/a |
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| Residue: | 359 |
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| Sequence: | MAPNGTASSFCLDSTACKITITVVLAVLILITVAGNVVVCLAVGLNRRLRNLTNCFIVSL
AITDLLLGLLVLPFSAIYQLSCKWSFGKVFCNIYTSLDVMLCTASILNLFMISLDRYCAV
MDPLRYPVLVTPVRVAISLVLIWVISITLSFLSIHLGWNSRNETSKGNHTTSKCKVQVNE
VYGLVDGLVTFYLPLLIMCITYYRIFKVARDQAKRINHISSWKAATIREHKATVTLAAVM
GAFIICWFPYFTAFVYRGLRGDDAINEVLEAIVLWLGYANSALNPILYAALNRDFRTGYQ
QLFCCRLANRNSHKTSLRSNASQLSRTQSREPRQQEEKPLKLQVWSGTEVTAPQGATDR
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| BDBM50356878 |
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| n/a |
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| Name | BDBM50356878 |
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| Synonyms: | CHEMBL1915534 |
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| Type | Small organic molecule |
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| Emp. Form. | C14H25N5 |
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| Mol. Mass. | 263.3818 |
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| SMILES | CC(C)(C)CCNc1cc(N[C@H]2CCNC2)ncn1 |r| |
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| Structure | 
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