| Reaction Details |
|---|
 | Report a problem with these data |
| Target | Tyrosine-protein kinase Lyn |
|---|
| Ligand | BDBM50357348 |
|---|
| Substrate/Competitor | n/a |
|---|
| Meas. Tech. | ChEMBL_788549 (CHEMBL1918489) |
|---|
| IC50 | 19±n/a nM |
|---|
| Citation |  Kim, KH; Maderna, A; Schnute, ME; Hegen, M; Mohan, S; Miyashiro, J; Lin, L; Li, E; Keegan, S; Lussier, J; Wrocklage, C; Nickerson-Nutter, CL; Wittwer, AJ; Soutter, H; Caspers, N; Han, S; Kurumbail, R; Dunussi-Joannopoulos, K; Douhan, J; Wissner, A Imidazo[1,5-a]quinoxalines as irreversible BTK inhibitors for the treatment of rheumatoid arthritis. Bioorg Med Chem Lett21:6258-63 (2011) [PubMed] Article |
|---|
| More Info.: | Get all data from this article, Assay Method |
|---|
| |
| Tyrosine-protein kinase Lyn |
|---|
| Name: | Tyrosine-protein kinase Lyn |
|---|
| Synonyms: | JTK8 | LYN | LYN_HUMAN | Lck/Yes-related novel protein tyrosine kinase | Tyrosine-protein kinase Lyn (LYN) | V-yes-1 Yamaguchi sarcoma viral related oncogene homolog | p53Lyn | p56Lyn |
|---|
| Type: | Protein |
|---|
| Mol. Mass.: | 58575.92 |
|---|
| Organism: | Homo sapiens (Human) |
|---|
| Description: | P07948 |
|---|
| Residue: | 512 |
|---|
| Sequence: | MGCIKSKGKDSLSDDGVDLKTQPVRNTERTIYVRDPTSNKQQRPVPESQLLPGQRFQTKD
PEEQGDIVVALYPYDGIHPDDLSFKKGEKMKVLEEHGEWWKAKSLLTKKEGFIPSNYVAK
LNTLETEEWFFKDITRKDAERQLLAPGNSAGAFLIRESETLKGSFSLSVRDFDPVHGDVI
KHYKIRSLDNGGYYISPRITFPCISDMIKHYQKQADGLCRRLEKACISPKPQKPWDKDAW
EIPRESIKLVKRLGAGQFGEVWMGYYNNSTKVAVKTLKPGTMSVQAFLEEANLMKTLQHD
KLVRLYAVVTREEPIYIITEYMAKGSLLDFLKSDEGGKVLLPKLIDFSAQIAEGMAYIER
KNYIHRDLRAANVLVSESLMCKIADFGLARVIEDNEYTAREGAKFPIKWTAPEAINFGCF
TIKSDVWSFGILLYEIVTYGKIPYPGRTNADVMTALSQGYRMPRVENCPDELYDIMKMCW
KEKAEERPTFDYLQSVLDDFYTATEGQYQQQP
|
|
|
|---|
| BDBM50357348 |
|---|
| n/a |
|---|
| Name | BDBM50357348 |
|---|
| Synonyms: | CHEMBL1916906 |
|---|
| Type | Small organic molecule |
|---|
| Emp. Form. | C18H16FN5 |
|---|
| Mol. Mass. | 321.3515 |
|---|
| SMILES | CNc1cc2c(cc1F)nc(Nc1ccccc1C)c1cncn21 |
|---|
| Structure | 
|
|---|
Search and Browse
