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TargetProstanoid IP receptor
LigandBDBM50357637
Substrate/Competitorn/a
Meas. Tech.ChEMBL_788407
Ki 1800±n/a nM
Citation Iwahashi MNaganawa AKinoshita AShimabukuro ANishiyama TOgawa SMatsunaga YTsukamoto KOkada YMatsumoto RNambu FOumi ROdagaki YKatagi JYano KTani KNakai HToda M Discovery of new orally active prostaglandin D2 receptor antagonists. Bioorg Med Chem 19:6935-48 (2011) [PubMed]  Article
More Info.:Get all data from this article,  Assay Method
 
Prostanoid IP receptor
Name:Prostanoid IP receptor
Synonyms:PGI receptor | Prostacyclin (IP) Receptor | Prostacyclin receptor | Prostaglandin I | Prostaglandin I2 | Prostaglandin I2 receptor
Type:G Protein-Coupled Receptor (GPCR)
Mol. Mass.:40968.22
Organism:Homo sapiens (Human)
Description:The membranes prepared from human platelet were used in binding assay.
Residue:386
Sequence:
MADSCRNLTYVRGSVGPATSTLMFVAGVVGNGLALGILSARRPARPSAFAVLVTGLAATD
LLGTSFLSPAVFVAYARNSSLLGLARGGPALCDAFAFAMTFFGLASMLILFAMAVERCLA
LSHPYLYAQLDGPRCARLALPAIYAFCVLFCALPLLGLGQHQQYCPGSWCFLRMRWAQPG
GAAFSLAYAGLVALLVAAIFLCNGSVTLSLCRMYRQQKRHQGSLGPRPRTGEDEVDHLIL
LALMTVVMAVCSLPLTIRCFTQAVAPDSSSEMGDLLAFRFYAFNPILDPWVFILFRKAVF
QRLKLWVCCLCLGPAHGDSQTPLSQLASGRRDPRAPSAPVGKEGSCVPLSAWGEGQVEPL
PPTQQSSGSAVGTSSKAEASVACSLC
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BDBM50357637
n/a
NameBDBM50357637
Synonyms:CHEMBL1915677
TypeSmall organic molecule
Emp. Form.C27H27ClN2O5
Mol. Mass.494.967
SMILESCN1C[C@@H](COc2cc(C)c(cc2C)C(=O)Nc2cc(CC(O)=O)ccc2Cl)Oc2ccccc12 |r|
Structure
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