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| Reaction Details | |||
|---|---|---|---|
 | Report a problem with these data | ||
| Target | Mitogen-activated protein kinase 14 | ||
| Ligand | BDBM50357912 | ||
| Substrate/Competitor | n/a | ||
| Meas. Tech. | ChEMBL_787640 (CHEMBL1918093) | ||
| IC50 | 11±n/a nM | ||
| Citation |  Lumeras, W; Vidal, L; Vidal, B; Balagué, C; Orellana, A; Maldonado, M; Domínguez, M; Segarra, V; Caturla, F 1,7-Naphthyridine 1-oxides as novel potent and selective inhibitors of p38 mitogen activated protein kinase. J Med Chem54:7899-910 (2011) [PubMed] Article | ||
| More Info.: | Get all data from this article, Assay Method | ||
| Mitogen-activated protein kinase 14 | |||
| Name: | Mitogen-activated protein kinase 14 | ||
| Synonyms: | CSAID-binding protein | CSBP | CSBP1 | CSBP2 | CSPB1 | Cytokine suppressive anti-inflammatory drug-binding protein | MAP kinase 14 | MAP kinase MXI2 | MAP kinase p38 alpha | MAPK 14 | MAPK14 | MAX-interacting protein 2 | MK14_HUMAN | MXI2 | Mitogen-activated protein kinase p38 alpha | SAPK2A | Stress-activated protein kinase 2a | p38 MAP kinase alpha/beta | ||
| Type: | Serine/threonine-protein kinase | ||
| Mol. Mass.: | 41286.76 | ||
| Organism: | Homo sapiens (Human) | ||
| Description: | Q16539 | ||
| Residue: | 360 | ||
| Sequence: |
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| BDBM50357912 | |||
| n/a | |||
| Name | BDBM50357912 | ||
| Synonyms: | CHEMBL1916526 | ||
| Type | Small organic molecule | ||
| Emp. Form. | C24H18ClF2N3O2 | ||
| Mol. Mass. | 453.868 | ||
| SMILES | [O-][n+]1ccc2c(cc(nc2c1-c1c(F)cccc1F)N1CCOCC1)-c1ccccc1Cl |(-7.92,-37.22,;-6.58,-36.45,;-6.58,-34.91,;-5.25,-34.14,;-3.92,-34.9,;-2.59,-34.12,;-1.25,-34.9,;-1.25,-36.45,;-2.59,-37.22,;-3.92,-36.45,;-5.25,-37.22,;-5.25,-38.75,;-6.58,-39.53,;-7.92,-38.76,;-6.58,-41.06,;-5.24,-41.83,;-3.91,-41.05,;-3.91,-39.52,;-2.58,-38.74,;.09,-37.22,;.08,-38.76,;1.4,-39.53,;2.74,-38.77,;2.75,-37.23,;1.42,-36.45,;-2.58,-32.59,;-1.25,-31.82,;-1.25,-30.28,;-2.58,-29.51,;-3.92,-30.29,;-3.91,-31.83,;-5.25,-32.6,)| | ||
| Structure | 
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