Ki Summary

Reaction Details

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Target

Metabotropic glutamate receptor 4

Ligand

BDBM50358178

Substrate/Competitor

n/a

Meas. Tech.

ChEMBL_788856 (CHEMBL1924926)

EC50

370±n/a nM

Citation

Jones, CK; Engers, DW; Thompson, AD; Field, JR; Blobaum, AL; Lindsley, SR; Zhou, Y; Gogliotti, RD; Jadhav, S; Zamorano, R; Bogenpohl, J; Smith, Y; Morrison, R; Daniels, JS; Weaver, CD; Conn, PJ; Lindsley, CW; Niswender, CM; Hopkins, CR Discovery, synthesis, and structure-activity relationship development of a series of N-4-(2,5-dioxopyrrolidin-1-yl)phenylpicolinamides (VU0400195, ML182): characterization of a novel positive allosteric modulator of the metabotropic glutamate receptor 4 (mGlu(4)) with oral efficacy in an antiparkin J Med Chem54:7639-47 (2011) [PubMed] Article

More Info.:

Get all data from this article, Assay Method

Metabotropic glutamate receptor 4

Name:

Metabotropic glutamate receptor 4

Synonyms:

Type:

Protein

Mol. Mass.:

101899.95

Organism:

Homo sapiens (Human)

Description:

Q14833

Residue:

912

Sequence:

MPGKRGLGWWWARLPLCLLLSLYGPWMPSSLGKPKGHPHMNSIRIDGDITLGGLFPVHGR
GSEGKPCGELKKEKGIHRLEAMLFALDRINNDPDLLPNITLGARILDTCSRDTHALEQSL
TFVQALIEKDGTEVRCGSGGPPIITKPERVVGVIGASGSSVSIMVANILRLFKIPQISYA
STAPDLSDNSRYDFFSRVVPSDTYQAQAMVDIVRALKWNYVSTVASEGSYGESGVEAFIQ
KSREDGGVCIAQSVKIPREPKAGEFDKIIRRLLETSNARAVIIFANEDDIRRVLEAARRA
NQTGHFFWMGSDSWGSKIAPVLHLEEVAEGAVTILPKRMSVRGFDRYFSSRTLDNNRRNI
WFAEFWEDNFHCKLSRHALKKGSHVKKCTNRERIGQDSAYEQEGKVQFVIDAVYAMGHAL
HAMHRDLCPGRVGLCPRMDPVDGTQLLKYIRNVNFSGIAGNPVTFNENGDAPGRYDIYQY
QLRNDSAEYKVIGSWTDHLHLRIERMHWPGSGQQLPRSICSLPCQPGERKKTVKGMPCCW
HCEPCTGYQYQVDRYTCKTCPYDMRPTENRTGCRPIPIIKLEWGSPWAVLPLFLAVVGIA
ATLFVVITFVRYNDTPIVKASGRELSYVLLAGIFLCYATTFLMIAEPDLGTCSLRRIFLG
LGMSISYAALLTKTNRIYRIFEQGKRSVSAPRFISPASQLAITFSLISLQLLGICVWFVV
DPSHSVVDFQDQRTLDPRFARGVLKCDISDLSLICLLGYSMLLMVTCTVYAIKTRGVPET
FNEAKPIGFTMYTTCIVWLAFIPIFFGTSQSADKLYIQTTTLTVSVSLSASVSLGMLYMP
KVYIILFHPEQNVPKRKRSLKAVVTAATMSNKFTQKGNFRPNGEAKSELCENLEAPALAT
KQTYVTYTNHAI

BDBM50358178

n/a

Name

BDBM50358178

Synonyms:

CHEMBL1921959

Type

Small organic molecule

Emp. Form.

C20H18ClN3O3

Mol. Mass.

383.828

SMILES

Oc1c2CCCCc2c(O)n1-c1ccc(NC(=O)c2ccccn2)cc1Cl |(.26,-21.79,;1.4,-22.83,;2.91,-22.53,;3.69,-21.21,;5.21,-21.22,;5.97,-22.56,;5.19,-23.88,;3.66,-23.86,;2.63,-25,;2.94,-26.51,;1.23,-24.36,;-.09,-25.16,;-1.43,-24.42,;-2.75,-25.21,;-2.73,-26.75,;-4.05,-27.54,;-5.4,-26.79,;-5.42,-25.25,;-6.72,-27.59,;-6.69,-29.12,;-8,-29.92,;-9.36,-29.17,;-9.38,-27.63,;-8.06,-26.84,;-1.38,-27.5,;-.06,-26.71,;1.29,-27.46,)|

Structure