| Reaction Details |
|---|
 | Report a problem with these data |
| Target | Tyrosine-protein kinase Fgr |
|---|
| Ligand | BDBM50358204 |
|---|
| Substrate/Competitor | n/a |
|---|
| Meas. Tech. | ChEMBL_790094 (CHEMBL1925484) |
|---|
| IC50 | 697±n/a nM |
|---|
| Citation |  Sutherlin, DP; Bao, L; Berry, M; Castanedo, G; Chuckowree, I; Dotson, J; Folks, A; Friedman, L; Goldsmith, R; Gunzner, J; Heffron, T; Lesnick, J; Lewis, C; Mathieu, S; Murray, J; Nonomiya, J; Pang, J; Pegg, N; Prior, WW; Rouge, L; Salphati, L; Sampath, D; Tian, Q; Tsui, V; Wan, NC; Wang, S; Wei, B; Wiesmann, C; Wu, P; Zhu, BY; Olivero, A Discovery of a potent, selective, and orally available class I phosphatidylinositol 3-kinase (PI3K)/mammalian target of rapamycin (mTOR) kinase inhibitor (GDC-0980) for the treatment of cancer. J Med Chem54:7579-87 (2011) [PubMed] Article |
|---|
| More Info.: | Get all data from this article, Assay Method |
|---|
| |
| Tyrosine-protein kinase Fgr |
|---|
| Name: | Tyrosine-protein kinase Fgr |
|---|
| Synonyms: | FGR | FGR_HUMAN | Gardner-Rasheed feline sarcoma viral (v-fgr) oncogene homolog | Proto-oncogene c-Fgr | SRC | SRC2 | p55-Fgr | p58-Fgr | p58c-Fgr |
|---|
| Type: | protein |
|---|
| Mol. Mass.: | 59469.88 |
|---|
| Organism: | Homo sapiens (Human) |
|---|
| Description: | P09769 |
|---|
| Residue: | 529 |
|---|
| Sequence: | MGCVFCKKLEPVATAKEDAGLEGDFRSYGAADHYGPDPTKARPASSFAHIPNYSNFSSQA
INPGFLDSGTIRGVSGIGVTLFIALYDYEARTEDDLTFTKGEKFHILNNTEGDWWEARSL
SSGKTGCIPSNYVAPVDSIQAEEWYFGKIGRKDAERQLLSPGNPQGAFLIRESETTKGAY
SLSIRDWDQTRGDHVKHYKIRKLDMGGYYITTRVQFNSVQELVQHYMEVNDGLCNLLIAP
CTIMKPQTLGLAKDAWEISRSSITLERRLGTGCFGDVWLGTWNGSTKVAVKTLKPGTMSP
KAFLEEAQVMKLLRHDKLVQLYAVVSEEPIYIVTEFMCHGSLLDFLKNPEGQDLRLPQLV
DMAAQVAEGMAYMERMNYIHRDLRAANILVGERLACKIADFGLARLIKDDEYNPCQGSKF
PIKWTAPEAALFGRFTIKSDVWSFGILLTELITKGRIPYPGMNKREVLEQVEQGYHMPCP
PGCPASLYEAMEQTWRLDPEERPTFEYLQSFLEDYFTSAEPQYQPGDQT
|
|
|
|---|
| BDBM50358204 |
|---|
| n/a |
|---|
| Name | BDBM50358204 |
|---|
| Synonyms: | CHEMBL1922094 |
|---|
| Type | Small organic molecule |
|---|
| Emp. Form. | C23H30N8O3S |
|---|
| Mol. Mass. | 498.601 |
|---|
| SMILES | C[C@H](O)C(=O)N1CCN(Cc2sc3c(nc(nc3c2C)-c2cnc(N)nc2)N2CCOCC2)CC1 |r| |
|---|
| Structure | 
|
|---|
Search and Browse
