| Reaction Details |
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 | Report a problem with these data |
| Target | Diacylglycerol O-acyltransferase 1 |
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| Ligand | BDBM50358339 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_789309 (CHEMBL1924476) |
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| IC50 | 554±n/a nM |
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| Citation |  Yun, W; Ahmad, M; Chen, Y; Gillespie, P; Conde-Knape, K; Kazmer, S; Li, S; Qian, Y; Taub, R; Wertheimer, SJ; Whittard, T; Bolin, D Discovery and optimization of 2-phenyloxazole derivatives as diacylglycerol acyltransferase-1 inhibitors. Bioorg Med Chem Lett21:7205-9 (2011) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Diacylglycerol O-acyltransferase 1 |
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| Name: | Diacylglycerol O-acyltransferase 1 |
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| Synonyms: | ACAT-related gene product 1 | AGRP1 | Acyl coA-diacylglycerol acyl transferase 1 (DGAT1) | DGAT | DGAT1 | DGAT1_HUMAN | Diacylglycerol Acyltransferase (DGAT1) | Diacylglycerol O-acyltransferase 1 | Diacylglycerol O-acyltransferase 1 (DGAT1) | Diglyceride acyltransferase |
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| Type: | Protein |
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| Mol. Mass.: | 55297.82 |
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| Organism: | Homo sapiens (Human) |
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| Description: | O75907 |
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| Residue: | 488 |
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| Sequence: | MGDRGSSRRRRTGSRPSSHGGGGPAAAEEEVRDAAAGPDVGAAGDAPAPAPNKDGDAGVG
SGHWELRCHRLQDSLFSSDSGFSNYRGILNWCVVMLILSNARLFLENLIKYGILVDPIQV
VSLFLKDPYSWPAPCLVIAANVFAVAAFQVEKRLAVGALTEQAGLLLHVANLATILCFPA
AVVLLVESITPVGSLLALMAHTILFLKLFSYRDVNSWCRRARAKAASAGKKASSAAAPHT
VSYPDNLTYRDLYYFLFAPTLCYELNFPRSPRIRKRFLLRRILEMLFFTQLQVGLIQQWM
VPTIQNSMKPFKDMDYSRIIERLLKLAVPNHLIWLIFFYWLFHSCLNAVAELMQFGDREF
YRDWWNSESVTYFWQNWNIPVHKWCIRHFYKPMLRRGSSKWMARTGVFLASAFFHEYLVS
VPLRMFRLWAFTGMMAQIPLAWFVGRFFQGNYGNAAVWLSLIIGQPIAVLMYVHDYYVLN
YEAPAAEA
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| BDBM50358339 |
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| n/a |
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| Name | BDBM50358339 |
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| Synonyms: | CHEMBL1922688 |
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| Type | Small organic molecule |
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| Emp. Form. | C19H17F3N4O3 |
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| Mol. Mass. | 406.3585 |
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| SMILES | CN(CCO)c1ccc(NC(=O)c2nc(oc2C(F)(F)F)-c2ccccc2)cn1 |
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| Structure | 
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