Reaction Details |
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Target | Diacylglycerol O-acyltransferase 1 |
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Ligand | BDBM50341760 |
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Substrate/Competitor | n/a |
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Meas. Tech. | ChEMBL_789313 (CHEMBL1924480) |
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IC50 | 120±n/a nM |
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Citation | Yun, W; Ahmad, M; Chen, Y; Gillespie, P; Conde-Knape, K; Kazmer, S; Li, S; Qian, Y; Taub, R; Wertheimer, SJ; Whittard, T; Bolin, D Discovery and optimization of 2-phenyloxazole derivatives as diacylglycerol acyltransferase-1 inhibitors. Bioorg Med Chem Lett21:7205-9 (2011) [PubMed] Article |
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More Info.: | Get all data from this article, Assay Method |
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Diacylglycerol O-acyltransferase 1 |
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Name: | Diacylglycerol O-acyltransferase 1 |
Synonyms: | DGAT1_RAT | Dgat | Dgat1 | Diacyl Glycerolacyltransferase 1 (DGAT-1) | Diacylglycerol O-acyltransferase 1 | Diglyceride acyltransferase |
Type: | Multi-pass membrane protein |
Mol. Mass.: | 56890.70 |
Organism: | Rattus norvegicus (rat) |
Description: | n/a |
Residue: | 498 |
Sequence: | MGDRGGAGSSRRRRTGSRVSVQGGSGPKVEEDEVREAAVSPDLGAGGDAPAPAPAPAHTR
DKDRQTSVGDGHWELRCHRLQDSLFSSDSGFSNYRGILNWCVVMLILSNARLSLENLIKY
GILVDPIQVVSLFLKDPYSWPAPCLIIASNIFIVATFQIEKRLSVGALTEQMGLLLHVVN
LATIICFPAAVALLVESITPVGSLFALASYSIIFLKLSSYRDVNLWCRQRRVKAKAVSAG
KKVSGAAAQNTVSYPDNLTYRDLYYFIFAPTLCYELNFPRSPRIRKRFLLRRVLEMLFFT
QLQVGLIQQWMVPTIQNSMKPFKDMDYSRIIERLLKLAVPNHLIWLIFFYWLFHSCLNAV
AELLQFGDREFYRDWWNAESVTYFWQNWNIPVHKWCIRHFYKPMLRLGSNKWMARTGVFW
ASAFFHEYLVSIPLRMFRLWAFTAMMAQVPLAWIVNRFFQGNYGNAAVWVTLIIGQPVAV
LMYVHDYYVLNYDAPVGA
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BDBM50341760 |
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n/a |
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Name | BDBM50341760 |
Synonyms: | 2-Phenyl-5-trifluoromethyloxazole-4-carboxylic Acid{6-[(2-Methoxyethyl)methylamino]pyridin-3-yl}amide | CHEMBL1766813 |
Type | Small organic molecule |
Emp. Form. | C20H19F3N4O3 |
Mol. Mass. | 420.3851 |
SMILES | COCCN(C)c1ccc(NC(=O)c2nc(oc2C(F)(F)F)-c2ccccc2)cn1 |
Structure |
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