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TargetDiacylglycerol O-acyltransferase 1
LigandBDBM50341760
Substrate/Competitorn/a
Meas. Tech.ChEMBL_789313 (CHEMBL1924480)
IC50 120±n/a nM
Citation Yun, WAhmad, MChen, YGillespie, PConde-Knape, KKazmer, SLi, SQian, YTaub, RWertheimer, SJWhittard, TBolin, D Discovery and optimization of 2-phenyloxazole derivatives as diacylglycerol acyltransferase-1 inhibitors. Bioorg Med Chem Lett21:7205-9 (2011) [PubMed]  Article
More Info.:Get all data from this article,  Assay Method
 
Diacylglycerol O-acyltransferase 1
Name:Diacylglycerol O-acyltransferase 1
Synonyms:DGAT1_RAT | Dgat | Dgat1 | Diacyl Glycerolacyltransferase 1 (DGAT-1) | Diacylglycerol O-acyltransferase 1 | Diglyceride acyltransferase
Type:Multi-pass membrane protein
Mol. Mass.:56890.70
Organism:Rattus norvegicus (rat)
Description:n/a
Residue:498
Sequence:
MGDRGGAGSSRRRRTGSRVSVQGGSGPKVEEDEVREAAVSPDLGAGGDAPAPAPAPAHTR
DKDRQTSVGDGHWELRCHRLQDSLFSSDSGFSNYRGILNWCVVMLILSNARLSLENLIKY
GILVDPIQVVSLFLKDPYSWPAPCLIIASNIFIVATFQIEKRLSVGALTEQMGLLLHVVN
LATIICFPAAVALLVESITPVGSLFALASYSIIFLKLSSYRDVNLWCRQRRVKAKAVSAG
KKVSGAAAQNTVSYPDNLTYRDLYYFIFAPTLCYELNFPRSPRIRKRFLLRRVLEMLFFT
QLQVGLIQQWMVPTIQNSMKPFKDMDYSRIIERLLKLAVPNHLIWLIFFYWLFHSCLNAV
AELLQFGDREFYRDWWNAESVTYFWQNWNIPVHKWCIRHFYKPMLRLGSNKWMARTGVFW
ASAFFHEYLVSIPLRMFRLWAFTAMMAQVPLAWIVNRFFQGNYGNAAVWVTLIIGQPVAV
LMYVHDYYVLNYDAPVGA
Blast this sequence in BindingDB or PDB
  Blast E-value cutoff:
BDBM50341760
n/a
NameBDBM50341760
Synonyms:2-Phenyl-5-trifluoromethyloxazole-4-carboxylic Acid{6-[(2-Methoxyethyl)methylamino]pyridin-3-yl}amide | CHEMBL1766813
TypeSmall organic molecule
Emp. Form.C20H19F3N4O3
Mol. Mass.420.3851
SMILESCOCCN(C)c1ccc(NC(=O)c2nc(oc2C(F)(F)F)-c2ccccc2)cn1
Structure
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