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TargetDual specificity mitogen-activated protein kinase kinase 5
LigandBDBM50358430
Substrate/Competitorn/a
Meas. Tech.ChEMBL_789708 (CHEMBL1924834)
IC50 5700±n/a nM
Citation Ishikawa, TSeto, MBanno, HKawakita, YOorui, MTaniguchi, TOhta, YTamura, TNakayama, AMiki, HKamiguchi, HTanaka, THabuka, NSogabe, SYano, JAertgeerts, KKamiyama, K Design and synthesis of novel human epidermal growth factor receptor 2 (HER2)/epidermal growth factor receptor (EGFR) dual inhibitors bearing a pyrrolo[3,2-d]pyrimidine scaffold. J Med Chem54:8030-50 (2011) [PubMed]  Article
More Info.:Get all data from this article,  Assay Method
 
Dual specificity mitogen-activated protein kinase kinase 5
Name:Dual specificity mitogen-activated protein kinase kinase 5
Synonyms:MAP kinase kinase 5 | MAP2K5 | MAPK/ERK kinase 5 | MAPKK 5 | MEK5 | MKK5 | MP2K5_HUMAN | PRKMK5
Type:PROTEIN
Mol. Mass.:50110.16
Organism:Homo sapiens (Human)
Description:ChEMBL_1495740
Residue:448
Sequence:
MLWLALGPFPAMENQVLVIRIKIPNSGAVDWTVHSGPQLLFRDVLDVIGQVLPEATTTAF
EYEDEDGDRITVRSDEEMKAMLSYYYSTVMEQQVNGQLIEPLQIFPRACKPPGERNIHGL
KVNTRAGPSQHSSPAVSDSLPSNSLKKSSAELKKILANGQMNEQDIRYRDTLGHGNGGTV
YKAYHVPSGKILAVKVILLDITLELQKQIMSELEILYKCDSSYIIGFYGAFFVENRISIC
TEFMDGGSLDVYRKMPEHVLGRIAVAVVKGLTYLWSLKILHRDVKPSNMLVNTRGQVKLC
DFGVSTQLVNSIAKTYVGTNAYMAPERISGEQYGIHSDVWSLGISFMELALGRFPYPQIQ
KNQGSLMPLQLLQCIVDEDSPVLPVGEFSEPFVHFITQCMRKQPKERPAPEELMGHPFIV
QFNDGNAAVVSMWVCRALEERRSQQGPP
Blast this sequence in BindingDB or PDB
  Blast E-value cutoff:
BDBM50358430
n/a
NameBDBM50358430
Synonyms:CHEMBL1614725
TypeSmall organic molecule
Emp. Form.C26H25ClF3N5O3
Mol. Mass.547.957
SMILESCC(C)(O)CC(=O)NCCn1ccc2ncnc(Nc3ccc(Oc4cccc(c4)C(F)(F)F)c(Cl)c3)c12
Structure
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