| Reaction Details |
|---|
 | Report a problem with these data |
| Target | Mitogen-activated protein kinase 3 |
|---|
| Ligand | BDBM50358430 |
|---|
| Substrate/Competitor | n/a |
|---|
| Meas. Tech. | ChEMBL_789891 (CHEMBL1925198) |
|---|
| IC50 | >10000±n/a nM |
|---|
| Citation |  Ishikawa, T; Seto, M; Banno, H; Kawakita, Y; Oorui, M; Taniguchi, T; Ohta, Y; Tamura, T; Nakayama, A; Miki, H; Kamiguchi, H; Tanaka, T; Habuka, N; Sogabe, S; Yano, J; Aertgeerts, K; Kamiyama, K Design and synthesis of novel human epidermal growth factor receptor 2 (HER2)/epidermal growth factor receptor (EGFR) dual inhibitors bearing a pyrrolo[3,2-d]pyrimidine scaffold. J Med Chem54:8030-50 (2011) [PubMed] Article |
|---|
| More Info.: | Get all data from this article, Assay Method |
|---|
| |
| Mitogen-activated protein kinase 3 |
|---|
| Name: | Mitogen-activated protein kinase 3 |
|---|
| Synonyms: | ERK1 | ERK1/ERK2 | Extracellular signal-regulated kinase 1 | Extracellular signal-regulated kinase 1 (ERK1) | MAP kinase ERK1 | MAPK3 | MAPK3/MAPK7 | MK03_HUMAN | Mitogen-activated protein kinase | Mitogen-activated protein kinase 3 | PRKM3 |
|---|
| Type: | Protein |
|---|
| Mol. Mass.: | 43136.58 |
|---|
| Organism: | Homo sapiens (Human) |
|---|
| Description: | curated by PDB 4QTB |
|---|
| Residue: | 379 |
|---|
| Sequence: | MAAAAAQGGGGGEPRRTEGVGPGVPGEVEMVKGQPFDVGPRYTQLQYIGEGAYGMVSSAY
DHVRKTRVAIKKISPFEHQTYCQRTLREIQILLRFRHENVIGIRDILRASTLEAMRDVYI
VQDLMETDLYKLLKSQQLSNDHICYFLYQILRGLKYIHSANVLHRDLKPSNLLINTTCDL
KICDFGLARIADPEHDHTGFLTEYVATRWYRAPEIMLNSKGYTKSIDIWSVGCILAEMLS
NRPIFPGKHYLDQLNHILGILGSPSQEDLNCIINMKARNYLQSLPSKTKVAWAKLFPKSD
SKALDLLDRMLTFNPNKRITVEEALAHPYLEQYYDPTDEPVAEEPFTFAMELDDLPKERL
KELIFQETARFQPGVLEAP
|
|
|
|---|
| BDBM50358430 |
|---|
| n/a |
|---|
| Name | BDBM50358430 |
|---|
| Synonyms: | CHEMBL1614725 |
|---|
| Type | Small organic molecule |
|---|
| Emp. Form. | C26H25ClF3N5O3 |
|---|
| Mol. Mass. | 547.957 |
|---|
| SMILES | CC(C)(O)CC(=O)NCCn1ccc2ncnc(Nc3ccc(Oc4cccc(c4)C(F)(F)F)c(Cl)c3)c12 |
|---|
| Structure | 
|
|---|
Search and Browse
