| Reaction Details |
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 | Report a problem with these data |
| Target | Histamine H4 receptor |
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| Ligand | BDBM50358533 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_790129 (CHEMBL1926408) |
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| Ki | 2900±n/a nM |
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| Citation |  de Graaf, C; Kooistra, AJ; Vischer, HF; Katritch, V; Kuijer, M; Shiroishi, M; Iwata, S; Shimamura, T; Stevens, RC; de Esch, IJ; Leurs, R Crystal structure-based virtual screening for fragment-like ligands of the human histamine H(1) receptor. J Med Chem54:8195-206 (2011) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Histamine H4 receptor |
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| Name: | Histamine H4 receptor |
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| Synonyms: | AXOR35 | G-protein coupled receptor 105 | GPCR105 | GPRv53 | HH4R | HISTAMINE H4 | HRH4 | HRH4_HUMAN | Histamine H4 receptor | Histamine H4 receptor (H4R) | Histamine receptor (H3 and H4) | Pfi-013 | SP9144 |
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| Type: | G Protein-Coupled Receptor (GPCR) |
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| Mol. Mass.: | 44517.02 |
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| Organism: | Homo sapiens (Human) |
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| Description: | Binding assays were using CHO cells stably expressing hH4R receptors. |
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| Residue: | 390 |
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| Sequence: | MPDTNSTINLSLSTRVTLAFFMSLVAFAIMLGNALVILAFVVDKNLRHRSSYFFLNLAIS
DFFVGVISIPLYIPHTLFEWDFGKEICVFWLTTDYLLCTASVYNIVLISYDRYLSVSNAV
SYRTQHTGVLKIVTLMVAVWVLAFLVNGPMILVSESWKDEGSECEPGFFSEWYILAITSF
LEFVIPVILVAYFNMNIYWSLWKRDHLSRCQSHPGLTAVSSNICGHSFRGRLSSRRSLSA
STEVPASFHSERQRRKSSLMFSSRTKMNSNTIASKMGSFSQSDSVALHQREHVELLRARR
LAKSLAILLGVFAVCWAPYSLFTIVLSFYSSATGPKSVWYRIAFWLQWFNSFVNPLLYPL
CHKRFQKAFLKIFCIKKQPLPSQHSRSVSS
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| BDBM50358533 |
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| n/a |
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| Name | BDBM50358533 |
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| Synonyms: | CHEMBL1923522 |
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| Type | Small organic molecule |
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| Emp. Form. | C15H23N7 |
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| Mol. Mass. | 301.39 |
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| SMILES | CN1CCN(CC1)c1nc(N2CCCC2)c2cnn(C)c2n1 |
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| Structure | 
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